Mejias Stephanie Gonzalez, Ramphul Kamleshun
Treatment Unit, National Institute of Diabetes affiliated to the University Iberoamericana UNIBE, Santo Domingo, Dominican Republic.
Shanghai Xin Hua Hospital affiliated to the Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Arch Med Sci Atheroscler Dis. 2018 Feb 15;3:e35-e40. doi: 10.5114/amsad.2018.73527. eCollection 2018.
Peripheral arterial disease (PAD) is a major risk factor of coronary artery disease and a major complication of atherosclerosis. Peripheral arterial disease can be diagnosed with simple and low cost techniques. There are major risk factors of PAD that have been studied for different countries. However, no such study has been done for the Dominican Republic. We conducted a cross-sectional study to determine the prevalence of PAD and the risk factors among patients with diabetes in Santo Domingo, Dominican Republic.
Six hundred randomly chosen patients with previously diagnosed diabetes were enrolled in our study. Their blood pressure and ankle brachial index were calculated and a questionnaire was provided to gather information regarding gender, age, weight, ethnicity, known duration of diabetes along with any history of smoking, hypertension and hyperlipidemia. A physical examination was also done to assess for any active diabetic ulcers, previous foot ulcers and non-traumatic amputation. A microfilament test was conducted to check for peripheral neuropathy.
Eighty-four diabetic patients were diagnosed with PAD with a prevalence of 14% in Santo Domingo, Dominican Republic. Statistically significant associations ( < 0.05) was found for female gender, presence of active foot ulcers, history of past foot ulcer, non-traumatic amputation, hypertension, hyperlipidemia and peripheral neuropathy. Glycated hemoglobin (HbA), age and smoking were not statistically significant in our study.
Diabetic patients who are either female, have active foot ulcers, a history of past foot ulcer, non-traumatic amputation, hypertension, hyperlipidemia or peripheral neuropathy are more at risk of developing PAD.
外周动脉疾病（PAD）是冠状动脉疾病的主要危险因素，也是动脉粥样硬化的主要并发症。外周动脉疾病可用简单且低成本的技术进行诊断。针对不同国家，已对PAD的主要危险因素展开研究。然而，多米尼加共和国尚未开展此类研究。我们进行了一项横断面研究，以确定多米尼加共和国圣多明各糖尿病患者中PAD的患病率及其危险因素。
我们的研究纳入了600名随机选取的先前已确诊糖尿病的患者。计算他们血压和踝肱指数，并提供一份问卷以收集有关性别、年龄、体重、种族、已知糖尿病病程以及任何吸烟、高血压和高脂血症病史的信息。还进行了体格检查，以评估是否存在任何活动性糖尿病溃疡、既往足部溃疡和非创伤性截肢情况。进行了微丝试验以检查是否存在周围神经病变。
84名糖尿病患者被诊断为PAD，在多米尼加共和国圣多明各的患病率为14%。发现女性、存在活动性足部溃疡、既往足部溃疡病史、非创伤性截肢、高血压、高脂血症和周围神经病变存在统计学显著关联（<0.05）。糖化血红蛋白（HbA）、年龄和吸烟在我们的研究中无统计学意义。
女性、有活动性足部溃疡、既往足部溃疡病史、非创伤性截肢、高血压、高脂血症或周围神经病变的糖尿病患者发生PAD的风险更高。
