Lee Christopher L, Dietrich Max C, Desai Uma G, Das Ankur, Yu Suhong, Xiang Hong F, Jaffe C Carl, Hirsch Ariel E, Bloch B Nicolas
Franklin W. Olin College of Engineering, 1000 Olin Way, Needham MA 02492.
Department of Radiology Oncology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.
J Eng Sci Med Diagn Ther. 2018 Nov;1(4). doi: 10.1115/1.4040817. Epub 2018 Aug 6.
This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. The iterative process for designing the phantom based on user interaction and evaluation is described. Using the CyberKnife System at Boston Medical Center a treatment plan was successfully created and delivered. Dosage delivery results were validated through gamma index calculations based on radiochromic film measurements which yielded a 99.8% passing rate. This phantom is a demonstration of a methodology for incorporating high-contrast magnetic resonance imaging into computed-tomography-based radiotherapy treatment planning; moreover, it can be used to perform quality assurance.
本文介绍了一种用于前列腺癌外照射放疗的新型患者及器官特异性3D打印体模的设计演变、制造及测试。与当前实践中的体模不同，该体模可用于规划和验证针对个体患者的治疗方案。它包含一个前列腺模型，其中有一个主要的前列腺内病变、精囊、尿道、射精管、神经血管束、直肠壁以及由一系列T2加权/动态对比增强磁共振图像生成的阴茎球部。描述了基于用户交互和评估设计体模的迭代过程。在波士顿医疗中心使用射波刀系统成功创建并实施了治疗计划。通过基于放射变色胶片测量的伽马指数计算验证了剂量输送结果，通过率为99.8%。该体模展示了一种将高对比度磁共振成像纳入基于计算机断层扫描的放射治疗治疗计划的方法；此外，它可用于进行质量保证。
