Katamesh Ahmed A, Subaiea Gehad M, Mostafa Mahmoud, Ibrahim Mohamed, Alobaida Ahmed, El-Horany Hemat E, Khalifa Nasrin E, Qelliny Milad Reda, El Sayed Marwa Mohamed
Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.
Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.
ACS Omega. 2025 Aug 25;10(35):39350-39370. doi: 10.1021/acsomega.5c01642. eCollection 2025 Sep 9.
recent advancements in three-dimensional (3D) printing technology have transformed cancer care by enabling the development of highly personalized and efficient therapeutic solutions. This review provides a comprehensive overview of the latest 3D printing methodologies and their integration into oncology, highlighting their diverse applications across various cancer types.
key fabrication techniques, such as fused deposition modeling (FDM), stereolithography (SLA), and semisolid extrusion, are explored, highlighting their ability to produce intricate, patient-specific structures with tailored mechanical and biological properties. These technologies have revolutionized cancer treatment by creating anatomical models that enhance surgical planning, drug delivery systems that enable localized and controlled release, and patient-specific implants that improve clinical outcomes. The application of 3D printing has extended to diverse cancer types, including lungs, colorectal, breast, and ovarian cancers, facilitating the development of tumor microenvironment models for studying cancer progression, drug resistance, and treatment response. Additionally, 3D-printed molds and boluses have demonstrated improved precision in radiation therapy by ensuring accurate delivery tailored to individual patient anatomy. By bridging engineering and medicine, 3D printing offers a transformative approach for addressing the complexities of oncology.
this review highlights the transformative role of 3D printing in modern cancer care, emphasizing its capacity to drive innovation, enable personalized treatment strategies, and enhance precision, ultimately improving therapeutic outcomes and patient care. Furthermore, this review integrates the latest developments regarding the application of 3D printing technology in cancer treatment.
三维(3D)打印技术的最新进展通过推动高度个性化和高效治疗方案的开发,改变了癌症治疗方式。本综述全面概述了最新的3D打印方法及其在肿瘤学中的整合,突出了它们在各种癌症类型中的多样应用。
探讨了关键制造技术,如熔融沉积建模(FDM)、立体光刻(SLA)和半固体挤压,强调了它们生产具有定制机械和生物学特性的复杂、患者特异性结构的能力。这些技术通过创建增强手术规划的解剖模型、实现局部和控释的药物递送系统以及改善临床结果的患者特异性植入物,彻底改变了癌症治疗。3D打印的应用已扩展到多种癌症类型,包括肺癌、结直肠癌、乳腺癌和卵巢癌,促进了用于研究癌症进展、耐药性和治疗反应的肿瘤微环境模型的开发。此外,3D打印的模具和填充物通过确保根据个体患者解剖结构进行精确递送,在放射治疗中显示出更高的精度。通过将工程学与医学相结合,3D打印为解决肿瘤学的复杂性提供了一种变革性方法。
本综述强调了3D打印在现代癌症治疗中的变革性作用,强调了其推动创新、实现个性化治疗策略和提高精度的能力,最终改善治疗效果和患者护理。此外,本综述整合了3D打印技术在癌症治疗应用方面的最新进展。