Nicolaides K H, Rosen D, Rabinowitz R, Campbell S
Department of Obstetrics and Gynaecology, King's College Hospital, London, UK.
Fetal Ther. 1988;3(3):135-40. doi: 10.1159/000263345.
Hourly fetal urine production rate (HFUPR) and bladder filling and voiding were determined by real-time ultrasonography in 13 fetuses with open spina bifida (OSB) and compared with those of 101 normal fetuses from uncomplicated pregnancies at 16-40 weeks gestation. In normal pregnancy, the fetal bladder volume increases linearly with time and then decreases rapidly with micturition. The mean cycle length does not change significantly with gestation but both the mean bladder volume and HFUPR increase. In fetuses with OSB, ultrasonographic examination has demonstrated deviations from normal in both bladder filling and bladder emptying.
通过实时超声检查测定了13例脊柱裂（OSB）胎儿的每小时胎儿尿量生成率（HFUPR）以及膀胱充盈和排尿情况，并与101例妊娠16 - 40周、无并发症的正常妊娠胎儿进行了比较。在正常妊娠中，胎儿膀胱体积随时间呈线性增加，然后随着排尿迅速减小。平均周期长度随孕周变化不显著，但平均膀胱体积和HFUPR均增加。在脊柱裂胎儿中，超声检查显示膀胱充盈和排空均偏离正常。
