谷胱甘肽补充剂可改善阿尔茨海默病患者的认知能力：一种前进的方式。
Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward.
机构信息
Neuroimaging and Neurospectroscopy Laboratory (NINS), National Brain Research Centre, Gurgaon, India.
Florey Institute of Neuroscience and Mental Health, University of Melbourne Medical school campus, Melbourne, Australia.
出版信息
J Alzheimers Dis. 2019;68(2):531-535. doi: 10.3233/JAD-181054.
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD pathology. Glutathione (GSH) is a major antioxidant, and it is already known that GSH is depleted significantly in the hippocampal regions in mild cognitive impairment (MCI) and AD patients compared to healthy old subjects. Hence there is a serious discussion to improve the brain GSH level by supplementation. This editorial highlights the need for GSH supplementation for the cognitive enhancement in MCI and AD.
阿尔茨海默病（AD）是一种破坏性的神经退行性疾病，影响着全球数百万人。AD 的实际病因仍不清楚。氧化应激被认为是 AD 病理中的重要因素。谷胱甘肽（GSH）是一种主要的抗氧化剂，已知与健康老年受试者相比，轻度认知障碍（MCI）和 AD 患者的海马区 GSH 明显减少。因此，人们强烈讨论通过补充来提高大脑 GSH 水平。这篇社论强调了在 MCI 和 AD 中补充 GSH 以增强认知的必要性。
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