• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

靶向膜转运蛋白的半乳糖功能化金纳米颗粒用于向脑癌细胞递送谷胱甘肽

Galactose-Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells.

作者信息

Milano Francesca, Nito Alessia, Caputo Annalisa, Gaballo Antonio, Marradi Marco, Quarta Alessandra, Ragusa Andrea

机构信息

Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3-13, 50019, Sesto Fiorentino (FI), Italy.

CNR NANOTEC, Institute of Nanotechnology, Campus Ecotekne, 73100, Lecce, Italy.

出版信息

Chembiochem. 2025 Jul 11;26(13):e202500104. doi: 10.1002/cbic.202500104. Epub 2025 Jun 17.

DOI:10.1002/cbic.202500104
PMID:40407254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12247028/
Abstract

Glutathione (GSH), a tripeptide essential for maintaining redox balance in the human body, plays a critical role in protecting cells from oxidative stress. A deficiency in GSH is linked to increased oxidative damage and the progression of various disorders, including cancer and neurological diseases. Herein, gold nanoparticles (Au NPs) coated with GSH and further functionalized with galactose moieties are developed to selectively target glucose transporters (GLUT), which is overexpressed on the surface of the blood-brain barrier (BBB) and could be exploited for the selective recognition and internalization of the Au@GSH-Gal NPs, that could then exert an antioxidant effect. As a proof of concept, brain cancer cells are treated with Au@GSH-Gal NPs, evidencing their increased internalization and a significant reduction of HO-induced oxidative stress.

摘要

谷胱甘肽（GSH）是一种维持人体氧化还原平衡所必需的三肽，在保护细胞免受氧化应激方面发挥着关键作用。GSH缺乏与氧化损伤增加以及包括癌症和神经疾病在内的各种疾病的进展有关。在此，开发了涂覆有GSH并进一步用半乳糖部分功能化的金纳米颗粒（Au NPs），以选择性靶向葡萄糖转运蛋白（GLUT），其在血脑屏障（BBB）表面过度表达，可用于Au@GSH-Gal NPs的选择性识别和内化，进而发挥抗氧化作用。作为概念验证，用Au@GSH-Gal NPs处理脑癌细胞，证明其内化增加且HO诱导的氧化应激显著降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/60baaac5af6a/CBIC-26-e202500104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/6a08e9fd744b/CBIC-26-e202500104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/4df31604aa51/CBIC-26-e202500104-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/75aaa0bf9c78/CBIC-26-e202500104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/ab60c55e28a8/CBIC-26-e202500104-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/a25c21b404dd/CBIC-26-e202500104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/39ba57c2d93a/CBIC-26-e202500104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/89c0b2d541df/CBIC-26-e202500104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/60baaac5af6a/CBIC-26-e202500104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/6a08e9fd744b/CBIC-26-e202500104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/4df31604aa51/CBIC-26-e202500104-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/75aaa0bf9c78/CBIC-26-e202500104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/ab60c55e28a8/CBIC-26-e202500104-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/a25c21b404dd/CBIC-26-e202500104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/39ba57c2d93a/CBIC-26-e202500104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/89c0b2d541df/CBIC-26-e202500104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg

相似文献

1
Galactose-Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells.靶向膜转运蛋白的半乳糖功能化金纳米颗粒用于向脑癌细胞递送谷胱甘肽
Chembiochem. 2025 Jul 11;26(13):e202500104. doi: 10.1002/cbic.202500104. Epub 2025 Jun 17.
2
The Anti-Metastatic Properties of Glutathione-Stabilized Gold Nanoparticles-A Preliminary Study on Canine Osteosarcoma Cell Lines.谷胱甘肽稳定的金纳米颗粒的抗转移特性——对犬骨肉瘤细胞系的初步研究
Int J Mol Sci. 2025 Jun 25;26(13):6102. doi: 10.3390/ijms26136102.
3
Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM).乳酸包被的聚脲-siRNA树枝状复合物：一种针对胶质母细胞瘤（GBM）的基因治疗导向且基于代谢的策略。
Cancer Gene Ther. 2025 Apr 27. doi: 10.1038/s41417-025-00906-8.
4
Oxidative Stress and Low Glutathione in Common Ear, Nose, and Throat Conditions: A Systematic Review.常见耳鼻咽喉疾病中的氧化应激与低谷胱甘肽水平：一项系统综述
Altern Ther Health Med. 2016 Sep;22(5):44-50.
5
Functionalized Zinc Oxide Nanoparticles Conjugated With Artemisinin Against Luperox-Induced Oxidative Stress and Their Impact on Antioxidant Defense Mechanism.与青蒿素共轭的功能化氧化锌纳米颗粒对抗鲁珀罗克斯诱导的氧化应激及其对抗氧化防御机制的影响
J Biochem Mol Toxicol. 2025 Jul;39(7):e70380. doi: 10.1002/jbt.70380.
6
Tumor-Specific Activatable Nanopaltform Achieves Oxidative Stress Amplification and Reversal of Cisplatin Resistance to Provoke Enhanced Ferroptosis-Apoptosis Cancer Therapy.肿瘤特异性可激活纳米平台实现氧化应激放大和顺铂耐药性逆转，以激发增强的铁死亡-凋亡癌症治疗。
Mol Pharm. 2025 Jul 7;22(7):4158-4172. doi: 10.1021/acs.molpharmaceut.5c00406. Epub 2025 Jun 11.
7
Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review.健康成年人脑和血液中抗氧化剂谷胱甘肽水平随年龄变化的系统评价。
Neuroimage Clin. 2023;40:103503. doi: 10.1016/j.nicl.2023.103503. Epub 2023 Aug 26.
8
Tartary Buckwheat Peptides Prevent Oxidative Damage in Differentiated SOL8 Cells via a Mitochondria-Mediated Apoptosis Pathway.苦荞肽通过线粒体介导的凋亡途径预防分化的SOL8细胞中的氧化损伤。
Nutrients. 2025 Jul 2;17(13):2204. doi: 10.3390/nu17132204.
9
Short-Term Memory Impairment短期记忆障碍
10
Engineered nanoparticles as a promising drug delivery system for glioblastoma multiforme treatment.工程纳米颗粒作为一种用于多形性胶质母细胞瘤治疗的有前景的药物递送系统。
Ther Deliv. 2025 Jun;16(6):593-606. doi: 10.1080/20415990.2025.2484170. Epub 2025 Mar 25.

本文引用的文献

1
Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing.用于增强L-谷胱甘肽局部递送的创新型富含固体脂质纳米颗粒的水凝胶：一种抗老化的新方法。
Pharmaceutics. 2024 Dec 24;17(1):4. doi: 10.3390/pharmaceutics17010004.
2
Oxidative cell death in cancer: mechanisms and therapeutic opportunities.癌症中的氧化细胞死亡：机制与治疗机遇
Cell Death Dis. 2024 Aug 1;15(8):556. doi: 10.1038/s41419-024-06939-5.
3
Galactose: A Versatile Vector Unveiling the Potentials in Drug Delivery, Diagnostics, and Theranostics.
半乳糖：一种揭示药物递送、诊断及治疗诊断学潜力的多功能载体。
Pharmaceuticals (Basel). 2024 Feb 27;17(3):308. doi: 10.3390/ph17030308.
4
Drug delivery to the central nervous system.药物向中枢神经系统的递送。
Nat Rev Mater. 2022 Apr;7(4):314-331. doi: 10.1038/s41578-021-00394-w. Epub 2021 Dec 3.
5
Functionalized Nanomaterials Capable of Crossing the Blood-Brain Barrier.具有穿透血脑屏障能力的功能化纳米材料。
ACS Nano. 2024 Jan 23;18(3):1820-1845. doi: 10.1021/acsnano.3c10674. Epub 2024 Jan 9.
6
Enhanced Delivery of 5-Aminolevulinic Acid by Lecithin Invasomes in 3D Melanoma Cancer Model.通过脂筏入侵囊泡增强 5-氨基酮戊酸在 3D 黑色素瘤癌症模型中的递送。
Mol Pharm. 2023 Nov 6;20(11):5593-5606. doi: 10.1021/acs.molpharmaceut.3c00494. Epub 2023 Sep 27.
7
Role of neuroinflammation in neurodegeneration development.神经炎症在神经退行性变发展中的作用。
Signal Transduct Target Ther. 2023 Jul 12;8(1):267. doi: 10.1038/s41392-023-01486-5.
8
Comparative assessment of green and chemically synthesized glutathione capped silver nanoparticles for antioxidant, mosquito larvicidal and eco-toxicological activities.比较评估绿色和化学合成谷胱甘肽包裹的银纳米粒子的抗氧化、杀蚊幼虫和生态毒理学活性。
Sci Rep. 2023 May 19;13(1):8152. doi: 10.1038/s41598-023-35249-7.
9
The role of glutathione conjugation on the transcellular transport process of PEGylated liposomes across the blood brain barrier.谷胱甘肽结合在聚乙二醇化脂质体跨血脑屏障的细胞转运过程中的作用。
Int J Pharm. 2022 Oct 15;626:122152. doi: 10.1016/j.ijpharm.2022.122152. Epub 2022 Aug 30.
10
Recent Overview of Resveratrol's Beneficial Effects and Its Nano-Delivery Systems.白藜芦醇的有益作用及其纳米递药系统的最新概述。
Molecules. 2022 Aug 12;27(16):5154. doi: 10.3390/molecules27165154.