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靶向膜转运蛋白的半乳糖功能化金纳米颗粒用于向脑癌细胞递送谷胱甘肽

Galactose-Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells.

作者信息

Milano Francesca, Nito Alessia, Caputo Annalisa, Gaballo Antonio, Marradi Marco, Quarta Alessandra, Ragusa Andrea

机构信息

Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3-13, 50019, Sesto Fiorentino (FI), Italy.

CNR NANOTEC, Institute of Nanotechnology, Campus Ecotekne, 73100, Lecce, Italy.

出版信息

Chembiochem. 2025 Jul 11;26(13):e202500104. doi: 10.1002/cbic.202500104. Epub 2025 Jun 17.

DOI:10.1002/cbic.202500104
PMID:40407254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12247028/
Abstract

Glutathione (GSH), a tripeptide essential for maintaining redox balance in the human body, plays a critical role in protecting cells from oxidative stress. A deficiency in GSH is linked to increased oxidative damage and the progression of various disorders, including cancer and neurological diseases. Herein, gold nanoparticles (Au NPs) coated with GSH and further functionalized with galactose moieties are developed to selectively target glucose transporters (GLUT), which is overexpressed on the surface of the blood-brain barrier (BBB) and could be exploited for the selective recognition and internalization of the Au@GSH-Gal NPs, that could then exert an antioxidant effect. As a proof of concept, brain cancer cells are treated with Au@GSH-Gal NPs, evidencing their increased internalization and a significant reduction of HO-induced oxidative stress.

摘要

谷胱甘肽（GSH）是一种维持人体氧化还原平衡所必需的三肽，在保护细胞免受氧化应激方面发挥着关键作用。GSH缺乏与氧化损伤增加以及包括癌症和神经疾病在内的各种疾病的进展有关。在此，开发了涂覆有GSH并进一步用半乳糖部分功能化的金纳米颗粒（Au NPs），以选择性靶向葡萄糖转运蛋白（GLUT），其在血脑屏障（BBB）表面过度表达，可用于Au@GSH-Gal NPs的选择性识别和内化，进而发挥抗氧化作用。作为概念验证，用Au@GSH-Gal NPs处理脑癌细胞，证明其内化增加且HO诱导的氧化应激显著降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/60baaac5af6a/CBIC-26-e202500104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/6a08e9fd744b/CBIC-26-e202500104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/4df31604aa51/CBIC-26-e202500104-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/75aaa0bf9c78/CBIC-26-e202500104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/ab60c55e28a8/CBIC-26-e202500104-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/a25c21b404dd/CBIC-26-e202500104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/39ba57c2d93a/CBIC-26-e202500104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/89c0b2d541df/CBIC-26-e202500104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/60baaac5af6a/CBIC-26-e202500104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/6a08e9fd744b/CBIC-26-e202500104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/4df31604aa51/CBIC-26-e202500104-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/75aaa0bf9c78/CBIC-26-e202500104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/ab60c55e28a8/CBIC-26-e202500104-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/a25c21b404dd/CBIC-26-e202500104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/39ba57c2d93a/CBIC-26-e202500104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/89c0b2d541df/CBIC-26-e202500104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db77/12247028/5e28bd2c18b5/CBIC-26-e202500104-g008.jpg

相似文献

[1]
Galactose-Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells.

Chembiochem. 2025-7-11

[2]
The Anti-Metastatic Properties of Glutathione-Stabilized Gold Nanoparticles-A Preliminary Study on Canine Osteosarcoma Cell Lines.

Int J Mol Sci. 2025-6-25

[3]
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Cancer Gene Ther. 2025-4-27

[4]
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[5]
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J Biochem Mol Toxicol. 2025-7

[6]
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Mol Pharm. 2025-7-7

[7]
Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review.

Neuroimage Clin. 2023

[8]
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Nutrients. 2025-7-2

[9]
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[10]
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Ther Deliv. 2025-6

本文引用的文献

[1]
Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing.

Pharmaceutics. 2024-12-24

[2]
Oxidative cell death in cancer: mechanisms and therapeutic opportunities.

Cell Death Dis. 2024-8-1

[3]
Galactose: A Versatile Vector Unveiling the Potentials in Drug Delivery, Diagnostics, and Theranostics.

Pharmaceuticals (Basel). 2024-2-27

[4]
Drug delivery to the central nervous system.

Nat Rev Mater. 2022-4

[5]
Functionalized Nanomaterials Capable of Crossing the Blood-Brain Barrier.

ACS Nano. 2024-1-23

[6]
Enhanced Delivery of 5-Aminolevulinic Acid by Lecithin Invasomes in 3D Melanoma Cancer Model.

Mol Pharm. 2023-11-6

[7]
Role of neuroinflammation in neurodegeneration development.

Signal Transduct Target Ther. 2023-7-12

[8]
Comparative assessment of green and chemically synthesized glutathione capped silver nanoparticles for antioxidant, mosquito larvicidal and eco-toxicological activities.

Sci Rep. 2023-5-19

[9]
The role of glutathione conjugation on the transcellular transport process of PEGylated liposomes across the blood brain barrier.

Int J Pharm. 2022-10-15

[10]
Recent Overview of Resveratrol's Beneficial Effects and Its Nano-Delivery Systems.

Molecules. 2022-8-12

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