Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China.
J Ethnopharmacol. 2019 May 23;236:31-41. doi: 10.1016/j.jep.2019.02.032. Epub 2019 Feb 16.
Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials.
The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix.
Codonopsis Radix samples from Min county, Gansu province processed with different methods were taken as the materials, UPLC-ESI-Q-TOF-MS/MS analysis was conducted to identify the compounds and establish UPLC fingerprint. Meanwhile, hematopoietic and immunologic functions of Codonopsis Radix were investigated to obtain relevant pharmacological index. Then, the correlation analysis between chemical constituents in UPLC fingerprints and pharmacological effects was carried out. The plant name was confirmed to the database "The Plant List" (www.theplantlist.org).
According to the results of canonical correlation analysis, tryptophan, syringin, tangshenoside I, codonopyrrolidium A, lobetyolin and two unknown compounds might be the potential bioactive markers related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as the index compounds.
This study illustrated the underlying correlations between chemical constituents and pharmacological effects, explored the pharmacological material basis, and could lay a foundation for the improvement of quality standard of Codonopsis Radix.
党参是一种常用的中药，具有健脾补肺、养血生津的功效。此外，它还被用作重要的食品材料。
本研究旨在解释化学成分与药理作用之间的潜在相关性，并探讨党参的生物活性标志物。
以甘肃省岷县不同炮制方法的党参样品为材料，采用 UPLC-ESI-Q-TOF-MS/MS 分析鉴定化合物并建立 UPLC 指纹图谱。同时，考察党参的造血和免疫功能，获得相关药理指标。然后，对 UPLC 指纹图谱中的化学成分与药理作用进行相关性分析。植物名称根据数据库"The Plant List"（www.theplantlist.org）进行确认。
根据典型相关分析的结果，色氨酸、丁香苷、党参皂苷 I、党参吡咯烷 A、芦丁和两种未知化合物可能是与党参造血和免疫功能相关的潜在生物活性标志物，可以推荐作为指标化合物。
本研究阐明了化学成分与药理作用之间的潜在相关性，探讨了党参的药理物质基础，为党参质量标准的提高奠定了基础。
