主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.
作者信息
von Boehmer H, Haas W, Jerne N K
出版信息
Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42. doi: 10.1073/pnas.75.5.2439.
Abstract
Female murine T cells can respond to the Y antigen of male cells by generating cytotoxic T-killer lymphocytes. Responsiveness is linked to several H-2 genes. Two types of low responders can be distinguished: the B10.A(5R) (H-2i5) strain, a low responder because it lacks Y-specific precursor T cells able to differentiate into cytotoxic T-killer cells; and the CBA/J (H-2k) strain, a low responder because it lacks Y-specific T-helper cells able to support differentiation of T-killer cell precursors. B10.A(5R) stem cells differentiating in an x-irradiated (CBA/J X C57BL/6) (H-2k X H-2b)F1 host respond to Y antigen by generating T-killer cells whereas CBA/J stem cells do not. The results are consistent with the hypothesis that diversity of T-cell receptors is generated by somatic mutation of germ-line genes encoding specificity for self-H-2. A detailed account of this hypothesis is presented.
摘要
雌性小鼠T细胞可通过产生细胞毒性T杀伤淋巴细胞来响应雄性细胞的Y抗原。反应性与多个H-2基因相关。可区分出两种低反应者类型：B10.A(5R)（H-2i5）品系，是低反应者，因为它缺乏能够分化为细胞毒性T杀伤细胞的Y特异性前体T细胞；以及CBA/J（H-2k）品系，是低反应者，因为它缺乏能够支持T杀伤细胞前体分化的Y特异性T辅助细胞。在经X射线照射的（CBA/J×C57BL/6）（H-2k×H-2b）F1宿主中分化的B10.A(5R)干细胞通过产生T杀伤细胞来响应Y抗原，而CBA/J干细胞则不会。这些结果与以下假设一致，即T细胞受体的多样性是由编码对自身H-2特异性的种系基因的体细胞突变产生的。本文对这一假设进行了详细阐述。
相似文献
1
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42. doi: 10.1073/pnas.75.5.2439.
2
Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.在对H-Y抗原的细胞毒性反应中，辅助性细胞和杀伤性细胞的不同免疫应答基因。
J Exp Med. 1979 Nov 1;150(5):1134-42. doi: 10.1084/jem.150.5.1134.
3
Patterns of virus-immune T-cell responsiveness. Comparison of (H-2k X H-2b) leads to H-2b radiation chimeras and negatively selected H-2b lymphocytes.病毒免疫T细胞反应模式。（H-2k×H-2b）与H-2b辐射嵌合体及阴性选择的H-2b淋巴细胞的比较。
J Exp Med. 1979 Nov 1;150(5):1187-94. doi: 10.1084/jem.150.5.1187.
4
Dissecting h-2 restriction.
Nature. 1978 Jul 6;274(5666):12-3. doi: 10.1038/274012a0.
5
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.
6
Cytotoxic T-cell response to H-Y in 'non-responder' CBA mice.“无反应性”CBA小鼠对H-Y的细胞毒性T细胞反应。
Nature. 1980 May 1;285(5759):34-6. doi: 10.1038/285034a0.
7
Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction.H-2抗原表达对杀伤性T细胞特异性、分化及诱导的影响。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6401-5. doi: 10.1073/pnas.78.10.6401.
8
The role of H-2-linked genes in helper T-cell function. VI. Expression of Ir genes by helper T cells.H-2连锁基因在辅助性T细胞功能中的作用。VI. 辅助性T细胞中Ir基因的表达。
J Exp Med. 1979 Mar 1;149(3):780-5. doi: 10.1084/jem.149.3.780.
9
10
The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.触发病毒加自身特异性细胞毒性T细胞中的淋巴网状系统：T辅助的证据。
J Exp Med. 1978 Mar 1;147(3):897-911. doi: 10.1084/jem.147.3.897.
引用本文的文献
1
DCs at the center of help: Origins and evolution of the three-cell-type hypothesis.树突状细胞处于核心地位：三细胞假说的起源和演变。
J Exp Med. 2022 Jul 4;219(7). doi: 10.1084/jem.20211519. Epub 2022 May 11.
2
Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.迈向对适应性免疫的分子理解：年表，第三部分。
Front Immunol. 2014 Feb 4;5:29. doi: 10.3389/fimmu.2014.00029. eCollection 2014.
3
Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.由单纯疱疹病毒特异性细胞毒 H-2k T 淋巴细胞介导的抗 H-2Dd 同种反应与 H-2Dk 相关。
Immunogenetics. 1980;10(4):395-404. doi: 10.1007/BF01561589.
4
T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.对 Mls 基因座抗原发生反应的 T 淋巴细胞为 Lyt-1+、2-和 I-A 限制。
Immunogenetics. 1980;10(5):481-97. doi: 10.1007/BF01572583.
5
Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).鼠细胞毒性 T 细胞对甲病毒的反应主要与 H-2D(k) 相关。
Immunogenetics. 1978 Dec;7(1):551-61. doi: 10.1007/BF01844044.
6
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.CD40配体介导的相互作用参与记忆性CD8(+)细胞毒性T淋巴细胞（CTL）的产生，但在病毒感染后维持CTL记忆方面并非必需。
J Virol. 1998 Sep;72(9):7440-9. doi: 10.1128/JVI.72.9.7440-7449.1998.
7
Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.在缺乏CD4 T细胞或B细胞的情况下产生持久的CD8 T细胞记忆。
J Exp Med. 1996 May 1;183(5):2153-63. doi: 10.1084/jem.183.5.2153.
8
A transcriptional silencer controls the developmental expression of the CD4 gene.一种转录沉默子控制着CD4基因的发育表达。
EMBO J. 1994 Aug 1;13(15):3570-9. doi: 10.1002/j.1460-2075.1994.tb06664.x.
9
Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.来自共享双向启动子的人类TAP1和LMP2基因的协同调控。
J Exp Med. 1995 Apr 1;181(4):1459-71. doi: 10.1084/jem.181.4.1459.
10
Successful T cell priming in B cell-deficient mice.B细胞缺陷小鼠中成功的T细胞致敏。
J Exp Med. 1995 Oct 1;182(4):915-22. doi: 10.1084/jem.182.4.915.
本文引用的文献
1
The somatic generation of immune recognition.免疫识别的体细胞产生
Eur J Immunol. 1971 Jan;1(1):1-9. doi: 10.1002/eji.1830010102.
2
Allelic forms of a gene controlling the female immune response to the male antigen in mice.控制小鼠雌性对雄性抗原免疫反应的一个基因的等位基因形式。
Transplantation. 1971 Apr;11(4):426-8. doi: 10.1097/00007890-197104000-00017.
3
Genetics and immunology of sex-linked antigens.性连锁抗原的遗传学与免疫学
Adv Immunol. 1972;15:215-47. doi: 10.1016/s0065-2776(08)60686-0.
4
Role of major histocompatibility complex gene products in delayed-type hypersensitivity.主要组织相容性复合体基因产物在迟发型超敏反应中的作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2486-90. doi: 10.1073/pnas.73.7.2486.
5
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.病毒特异性T细胞介导的细胞溶解对H-2相容性的要求。所涉及的H-2K结构由H-2Kb突变小鼠定义的单个顺反子编码。
J Exp Med. 1976 Feb 1;143(2):437-43. doi: 10.1084/jem.143.2.437.
6
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.T细胞受体、免疫反应基因及其他组织相容性基因产物的功能与相互关系。
Transplant Rev. 1975;22:175-95. doi: 10.1111/j.1600-065x.1975.tb01559.x.
7
Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.独特型作为可变区标记：磷酸胆碱特异性T淋巴细胞和B淋巴细胞受体之间的相似性
Immunol Rev. 1977;34:3-33. doi: 10.1111/j.1600-065x.1977.tb00366.x.
8
The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.触发病毒加自身特异性细胞毒性T细胞中的淋巴网状系统：T辅助的证据。
J Exp Med. 1978 Mar 1;147(3):897-911. doi: 10.1084/jem.147.3.897.
9
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.细胞毒性T细胞在胸腺分化过程中学习对自身H-2的特异性。
Nature. 1978 Jan 19;271(5642):251-3. doi: 10.1038/271251a0.
10
H-2 gene complementation in cytotoxic T cell responses of female against male cells.雌性对雄性细胞的细胞毒性T细胞反应中的H-2基因互补作用。
Eur J Immunol. 1977 Jul;7(7):443-7. doi: 10.1002/eji.1830070708.
Zotero 插件