Unit for Thrombosis Research, Esbjerg, Hospital of South West Jutland, Denmark.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Thromb Res. 2019 Apr;176:46-53. doi: 10.1016/j.thromres.2019.02.009. Epub 2019 Feb 13.
Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available.
To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015.
PATIENTS/METHODS: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015. The rates were standardized to the age and sex distribution in 2006. Based on the hospitalization and prescription history of each patient, we assessed the risk profile and evaluated changes over time.
We identified 67,426 patients with a first-time VTE hospitalization. The age- and sex-standardized incidence rate increased from 12.6 (95% CI: 12.3-12.9) per 10,000 person years at risk in 2006 to 15.1 (95% CI: 14.7-15.4) in 2015, corresponding to an increase of 19.8%. The increase was due to a 73.9% increase in the standardized incidence rate of pulmonary embolism (PE), whereas no increase was observed for deep vein thrombosis. The risk profile changed with an increasing proportion of elderly patients and patients with comorbidity (proportion of patients with a Charlson's Comorbidity Index score of ≥1).
The hospitalization rate of first-time VTE, and particularly PE, has increased substantially within the last decade in Denmark. In addition, the risk profile of the VTE population has changed with more elderly and more patients with comorbidity being diagnosed. Further efforts are warranted to explore the changes in VTE epidemiology and the clinical implications.
静脉血栓栓塞症（VTE）具有重大的临床和公共卫生影响。然而，目前仅有少量关于反映当前临床实践的未选择人群中发病率的时间趋势数据。
研究丹麦 2006 年至 2015 年首次发生 VTE 的患者住院发病率和特征的时间趋势。
患者/方法：使用全国性的医疗保健登记处，我们计算了 2006 年至 2015 年首次发生 VTE 的每年住院率。这些比率根据 2006 年的年龄和性别分布进行了标准化。根据每位患者的住院和处方记录，我们评估了风险概况并评估了随时间的变化。
我们确定了 67426 例首次 VTE 住院患者。年龄和性别标准化发病率从 2006 年的每 10000 人年风险 12.6（95%CI：12.3-12.9）增加到 2015 年的 15.1（95%CI：14.7-15.4），增加了 19.8%。这种增加是由于肺栓塞（PE）的标准化发病率增加了 73.9%，而深静脉血栓形成的发病率没有增加。风险概况发生了变化，老年患者和合并症患者的比例增加（Charlson 合并症指数评分≥1 的患者比例）。
在过去十年中，丹麦首次发生 VTE（尤其是 PE）的住院率大幅增加。此外，VTE 患者的风险概况发生了变化，更多的老年患者和合并症患者被诊断出来。需要进一步努力探讨 VTE 流行病学的变化及其临床意义。
