Berlin-Brandenburg School for Regenerative Therapies (BSRT), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Laboratoire d'Imagerie Biomédicale (LIB), Sorbonne University, CNRS, INSERM, Paris, France; BleuSolid, Pomponne, France.
Ultrasound Med Biol. 2019 May;45(5):1234-1242. doi: 10.1016/j.ultrasmedbio.2019.01.008. Epub 2019 Feb 15.
The aim of this study was to estimate cortical porosity (Ct.Po) and cortical thickness (Ct.Th) using 500-kHz bi-directional axial transmission (AT). Ct.Th and Ct.Po were obtained at the tibia in 15 patients from a 2-D transverse isotropic free plate model fitted to measured guided wave dispersion curves. The velocities of the first arriving signal (υ) and A mode (υ) were also determined. Site-matched peripheral quantitative computed tomography (pQCT) provided volumetric cortical bone mineral density (Ct.vBMD) and Ct.Th. Good agreement was found between Ct.Th and Ct.Th (R = 0.62, root mean square error [RMSE] = 0.39 mm). Ct.vBMD correlated with Ct.Po (R = 0.57), υ (R = 0.43) and υ (R = 0.28). Furthermore, a significant correlation was found between AT and distal high-resolution pQCT. The measurement ofcortical parameters at the tibia using guided waves might improve the prediction of bone fractures in a cost-effective and radiation-free manner.
本研究旨在使用 500kHz 双向轴向传输（AT）技术估算皮质孔隙率（Ct.Po）和皮质厚度（Ct.Th）。在拟合了测量导波色散曲线的二维各向同性自由板模型后，从 15 名患者的胫骨中获得了 Ct.Th 和 Ct.Po。还确定了第一个到达信号（υ）和 A 模式（υ）的速度。与部位匹配的外周定量计算机断层扫描（pQCT）提供了体积皮质骨矿物质密度（Ct.vBMD）和 Ct.Th。Ct.Th 与 Ct.Th（R=0.62，均方根误差 [RMSE]=0.39mm）之间存在良好的一致性。Ct.vBMD 与 Ct.Po（R=0.57）、υ（R=0.43）和 υ（R=0.28）相关。此外，还发现 AT 与远端高分辨率 pQCT 之间存在显著相关性。使用导波技术测量胫骨的皮质参数可能以具有成本效益且无辐射的方式改善骨折预测。
