Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Belgium.
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; University of Genoa, Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino, Italy.
Reprod Biol. 2019 Mar;19(1):1-5. doi: 10.1016/j.repbio.2019.02.003. Epub 2019 Feb 15.
Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy adopted by clinicians in case of elevated progesterone. Nonetheless, recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affect not only implantation, but also embryo quality.
在体外受精刺激周期的晚期卵泡期，孕激素升高是一种常见现象，会对结果产生负面影响。多年来的证据表明，晚期卵泡期孕激素升高与子宫内膜容受性之间存在直接关系。在这方面，对于孕激素升高的情况，临床医生最常采用的策略是选择性冷冻保存所有优质胚胎，并在随后的冷冻/解冻周期中进行移植。然而，最近的证据表明，考虑到这种增加不仅会影响着床，还会影响胚胎质量，选择性冷冻保存可能并不能完全解决与孕激素升高相关的妊娠结局降低的问题。
