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本文引用的文献

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Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction of Terminalia chebula.诃子乙酸乙酯部位的镇咳疗效及安全性概况
ISRN Pharmacol. 2013 Aug 19;2013:256934. doi: 10.1155/2013/256934. eCollection 2013.
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Anti-inflammatory, anti-lipid peroxidative, antioxidant and membrane stabilizing activities of hydroalcoholic extract of Terminalia chebula fruits.诃子水醇提取物的抗炎、抗脂质过氧化、抗氧化和稳定细胞膜活性。
Pharm Biol. 2013 Dec;51(12):1515-20. doi: 10.3109/13880209.2013.799709. Epub 2013 Sep 5.
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Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta-carotene, and canthaxanthin.虾青素、β-胡萝卜素和角黄素在化学发光模型中的活性氧清除活性及对大鼠嗜铬细胞瘤细胞的神经保护作用。
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Screening of medicinal plants for PPARα and PPARγ activation and evaluation of their effects on glucose uptake and 3T3-L1 adipogenesis.筛选具有 PPARα 和 PPARγ 激活作用的药用植物，并评价它们对葡萄糖摄取和 3T3-L1 脂肪生成的影响。
Planta Med. 2013 Aug;79(12):1084-95. doi: 10.1055/s-0033-1350620. Epub 2013 Jul 22.
5
Terminalia chebula extract protects OGD-R induced PC12 cell death and inhibits lps induced microglia activation.使君子提取物可保护 OGD-R 诱导的 PC12 细胞死亡并抑制 LPS 诱导的小胶质细胞激活。
Molecules. 2013 Mar 19;18(3):3529-42. doi: 10.3390/molecules18033529.
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Epidemiology of Alzheimer disease.阿尔茨海默病的流行病学。
Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a006239. doi: 10.1101/cshperspect.a006239.
7
Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats.鞣花酸可减轻链脲佐菌素诱导的糖尿病大鼠脑和坐骨神经的氧化应激，并改善其脑组织病理学变化。
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Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts.没食子诃子提取物的植物化学成分、抗氧化活性和神经保护作用。
Evid Based Complement Alternat Med. 2012;2012:125247. doi: 10.1155/2012/125247. Epub 2011 Jul 5.
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Extract from Terminalia chebula seeds protect against experimental ischemic neuronal damage via maintaining SODs and BDNF levels.诃子提取物通过维持 SOD 和 BDNF 水平来保护实验性缺血性神经元损伤。
Neurochem Res. 2011 Nov;36(11):2043-50. doi: 10.1007/s11064-011-0528-9. Epub 2011 Jun 12.

提取物和鞣花酸对PC12细胞的神经保护作用

NEUROPROTECTIVE EFFECT OF EXTRACTS AND ELLAGIC ACID IN PC12 CELLS.

作者信息

Shen Yuh-Chiang, Juan Chi-Wen, Lin Che-San, Chen Chien-Chih, Chang Chia-Lin

机构信息

National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C.).

Institute of Biomedical Sciences, National Chung Hsing University, Taichung City, Taiwan (R.O.C.).

出版信息

Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):22-30. doi: 10.21010/ajtcam.v14i4.3. eCollection 2017.

DOI:10.21010/ajtcam.v14i4.3
PMID:28638863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5471469/
Abstract

BACKGROUND

Alzheimer's disease (AD) is one of the common neurodegenerative disorders among elderly. The purpose of this study was to determine the neuroprotective effect and mechanisms of action underlying the extracts and ellagic acid by using beta-amyloid (Aβ)-induced cell toxicity in an undifferentiated pheochromocytoma (PC12) cell line.

MATERIALS AND METHODS

The extracts were prepared using the methanol, water, and 95% ethanol. Specifically, the ellagic acid was obtained in our laboratory. Assays including cell toxicity and changes in intracellular reactive oxygen species (ROS) and calcium level were evaluated to examine the neuroprotective effects and mechanisms of the extracts and ellagic acid.

RESULTS

The methanolic and water extracts of and ellagic acid exhibited the strongest neuroprotective activity against Aβ-induced PC12 cell damages at 0.5-5.0 μg/ml. The ellagic acid also exhibited partial neuroprotective activity against HO-induced PC12 cell damages at 0.5-5.0 μg/ml. The methanolic and water extracts of and ellagic acid protected PC12 cells from Aβ-mediated cell damages and enhanced cell viability thorough two key mechanisms by: (1) inhibiting ROS production and (2) reducing calcium ion influx.

CONCLUSION

The represents a promising plant-source as medicine in the application for the treatment of AD. Further investigation focusing on the active component of extracts e.g., ellagic acid is crucial to verify the neuroprotective efficacy and mechanisms .

摘要

背景

阿尔茨海默病（AD）是老年人常见的神经退行性疾病之一。本研究的目的是通过在未分化的嗜铬细胞瘤（PC12）细胞系中利用β-淀粉样蛋白（Aβ）诱导的细胞毒性，来确定提取物和鞣花酸的神经保护作用及其作用机制。

材料与方法

使用甲醇、水和95%乙醇制备提取物。具体而言，鞣花酸是在我们实验室获得的。通过评估包括细胞毒性以及细胞内活性氧（ROS）和钙水平变化等测定，来研究提取物和鞣花酸的神经保护作用及其机制。

结果

提取物的甲醇提取物和水提取物以及鞣花酸在0.5 - 5.0μg/ml浓度下对Aβ诱导的PC12细胞损伤表现出最强的神经保护活性。鞣花酸在0.5 - 5.0μg/ml浓度下对过氧化氢（HO）诱导的PC12细胞损伤也表现出部分神经保护活性。提取物的甲醇提取物和水提取物以及鞣花酸通过两种关键机制保护PC12细胞免受Aβ介导的细胞损伤并提高细胞活力：（1）抑制ROS产生；（2）减少钙离子内流。

结论

该提取物在治疗AD的应用中代表了一种有前景的植物源药物。进一步聚焦于提取物的活性成分如鞣花酸的研究对于验证神经保护功效及其机制至关重要。