Liu Qingqing, Yang Jin, Zhang Jun, Zhao Fanfan, Feng Xiaojie, Wang Xue, Lyu Jun
Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Front Pharmacol. 2019 Feb 4;10:62. doi: 10.3389/fphar.2019.00062. eCollection 2019.
Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection of intensive-care units (ICUs). Accurate, timely diagnosis enables early VAP patients to receive appropriate therapies and reduce the occurrence of complication. However, so far clinical datas regarding the epidemiology and mortality of VAP are still limited. Medical Information Mart for Intensive Care (MIMIC) database is a free, open and public resource about ICU research database. MIMIC database is a free, open, public database that collects information on more than 40,000 ICU patients who are predominantly white people. Therefore, the purpose of the present study is to observe and describe the clinical characteristics of VAP patients in ICU from the MIMIC database. A total of 418 patients were enrolled in the study. General information, ventilator use information, microbiology information, antibiotic use information, and some nursing-related information were extracted to describe and analyze the clinical features of VAP patients. The results of the study showed that patients with one or three pathogens were the most. The main pathogens were YEAST (16.71%), STAPH AUREUS COAG+ (11.63%), , COAGULASE NEGATIVE (8.68%), GRAM NEGATIVE ROD (S) (6.14%), and (5.73%). Patients using 4 antibiotics were the most. The top five antibiotics in the largest proportion were synthetic antibacterials (24.66%), peptides (20.13%), cephalosporins (19.60%), penicillins (13.54%), and aminoglycosides (5.27%). This study summarizes the common pathogens of VAP and the antibiotics commonly used in the treatment of VAP by describing the clinical information of 418 patients with VAP in the MIMIC database. In clinical treatment, we should pay attention to aseptic operation, develop appropriate antibacterial measures, closely monitor the pathogens of VAP infection, and use antibiotics in a timely manner to control the occurrence and development of VAP.
呼吸机相关性肺炎（VAP）是重症监护病房（ICU）常见且严重的医院感染。准确、及时的诊断能使早期VAP患者接受恰当治疗并减少并发症的发生。然而，迄今为止，关于VAP流行病学和死亡率的临床数据仍然有限。重症监护医学信息集市（MIMIC）数据库是一个免费、开放的公共ICU研究数据库资源。MIMIC数据库是一个免费、开放的公共数据库，收集了40000多名以白种人为主的ICU患者的信息。因此，本研究的目的是从MIMIC数据库中观察和描述ICU中VAP患者的临床特征。本研究共纳入418例患者。提取了一般信息、呼吸机使用信息、微生物学信息、抗生素使用信息以及一些护理相关信息，以描述和分析VAP患者的临床特征。研究结果显示，感染一种或三种病原体的患者最多。主要病原体为酵母菌（16.71%）、凝固酶阳性金黄色葡萄球菌（11.63%）、凝固酶阴性葡萄球菌（8.68%）、革兰氏阴性杆菌（6.14%）以及……（5.73%）。使用4种抗生素的患者最多。使用比例最高的前五种抗生素分别是合成抗菌药（24.66%）、肽类（20.13%）、头孢菌素（19.60%）、青霉素（13.54%）和氨基糖苷类（5.27%）。本研究通过描述MIMIC数据库中418例VAP患者的临床信息，总结了VAP的常见病原体以及治疗VAP常用的抗生素。在临床治疗中，应注意无菌操作，制定恰当的抗菌措施，密切监测VAP感染的病原体，并及时使用抗生素以控制VAP的发生和发展。
