Department of Chemistry and Biochemistry, University of Denver, Denver, CO, 80208, USA.
Appl Microbiol Biotechnol. 2019 Apr;103(7):2903-2912. doi: 10.1007/s00253-019-09684-4. Epub 2019 Feb 18.
Mycofactocin is a member of the rapidly growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Although the mycofactocin biosynthetic pathway is widely distributed among Mycobacterial species, the structure, function, and biosynthesis of the pathway product remain unknown. This mini-review will discuss the current state of knowledge regarding the mycofactocin biosynthetic pathway. In particular, we focus on the architecture and distribution of the mycofactocin biosynthetic cluster, mftABCDEF, among the Actinobacteria phylum. We discuss the potential molecular and physiological role of mycofactocin. We review known biosynthetic steps involving MftA, MftB, MftC, and MftE and relate them to pyrroloquinoline quinone biosynthesis. Lastly, we propose the function of the remaining putative biosynthetic enzymes, MftD and MftF.
类真菌菌素是一类快速增长的核糖体合成和翻译后修饰肽（RiPP）天然产物。尽管类真菌菌素生物合成途径在分枝杆菌属中广泛分布，但该途径产物的结构、功能和生物合成仍不清楚。本综述将讨论类真菌菌素生物合成途径的最新研究进展。特别地，我们集中讨论放线菌门中类真菌菌素生物合成簇 mftABCDEF 的结构和分布。我们讨论了类真菌菌素的潜在分子和生理作用。我们综述了涉及 MftA、MftB、MftC 和 MftE 的已知生物合成步骤，并将其与吡咯并喹啉醌生物合成联系起来。最后，我们提出了剩余假定的生物合成酶 MftD 和 MftF 的功能。
