Signal Transduction Pathways in Ageing.
作者信息
Slack Cathy, Tullet Jennifer
机构信息
School of Life and Health Sciences, Aston University, Birmingham, UK.
School of Biosciences, University of Kent, Canterbury, Kent, UK.
出版信息
Subcell Biochem. 2018;90:323-350. doi: 10.1007/978-981-13-2835-0_11.
PMID:30779014
Abstract
It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.
摘要
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