环状 RNA 参与调控与年龄相关的通路。
Circular RNAs Involved in the Regulation of the Age-Related Pathways.
机构信息
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
出版信息
Int J Mol Sci. 2022 Sep 9;23(18):10443. doi: 10.3390/ijms231810443.
Circular RNAs (circRNAs) are a class of covalently circular noncoding RNAs that have been extensively studied in recent years. Aging is a process related to functional decline that is regulated by signal transduction. An increasing number of studies suggest that circRNAs can regulate aging and multiple age-related diseases through their involvement in age-related signaling pathways. CircRNAs perform several biological functions, such as acting as miRNA sponges, directly interacting with proteins, and regulating transcription and translation to proteins or peptides. Herein, we summarize research progress on the biological functions of circRNAs in seven main age-related signaling pathways, namely, the insulin-insulin-like, PI3K-AKT, mTOR, AMPK, FOXO, p53, and NF-κB signaling pathways. In these pathways, circRNAs mainly function as miRNA sponges. In this review, we suggest that circRNAs are widely involved in the regulation of the main age-related pathways and are potential biomarkers for aging and age-related diseases.
环状 RNA（circRNAs）是一类共价环状非编码 RNA，近年来受到广泛研究。衰老过程是一种受信号转导调控的功能下降过程。越来越多的研究表明，circRNAs 可以通过参与与年龄相关的信号通路来调节衰老和多种与年龄相关的疾病。circRNAs 具有多种生物学功能，例如作为 miRNA 海绵、直接与蛋白质相互作用以及调节转录和翻译为蛋白质或肽。在此，我们总结了 circRNAs 在七个主要与年龄相关的信号通路（胰岛素-胰岛素样、PI3K-AKT、mTOR、AMPK、FOXO、p53 和 NF-κB 信号通路）中的生物学功能的研究进展。在这些通路中，circRNAs 主要作为 miRNA 海绵发挥作用。在这篇综述中，我们提出 circRNAs 广泛参与主要与年龄相关的通路的调节，并且是衰老和与年龄相关的疾病的潜在生物标志物。
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