From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.
Arch Pathol Lab Med. 2019 Nov;143(11):1416-1419. doi: 10.5858/arpa.2018-0224-RS. Epub 2019 Feb 19.
High-grade sinonasal carcinomas are a cohort of malignant epithelial neoplasms arising in the sinonasal cavities with distinct, ominous morphologic features or lacking well-differentiated features that might otherwise classify them as less biologically worrisome. Recent advances in molecular profiling have led to the identification of several distinct tumor entities previously grouped together. These molecularly distinct lesions include (midline) carcinoma, ()-deficient carcinoma, -deficient sinonasal carcinoma, and novel -mutant sinonasal undifferentiated carcinoma, in addition to the previously described lymphoepithelial carcinoma that may also be included in the differential diagnosis. The discovery of these distinct molecular tumor profiles may have significant clinical impact as targeted molecular-based therapeutics continue to evolve, and they may offer some respite for patients who have these highly aggressive cancers.
高级鼻腔鼻窦癌是一组发生在鼻腔鼻窦的恶性上皮性肿瘤，具有明显的形态学特征或缺乏分化良好的特征，如果不然，这些特征可能会将其归类为生物学上不那么令人担忧的肿瘤。最近在分子谱分析方面的进展导致了对以前归类在一起的几个不同肿瘤实体的识别。这些分子上不同的病变包括（中线）癌、（）缺陷型癌、-缺陷型鼻腔鼻窦癌和新型-突变型鼻腔鼻窦未分化癌，此外还有以前描述的可能也包含在鉴别诊断中的淋巴上皮癌。随着靶向分子治疗的不断发展，这些不同的分子肿瘤特征的发现可能会对临床产生重大影响，并且可能为患有这些高度侵袭性癌症的患者提供一些缓解。
