Department of Microbiology and Quality Control Laboratory, University of Veterinary and Animal Lahore, 54000, Pakistan.
Infect Genet Evol. 2019 Jun;70:80-83. doi: 10.1016/j.meegid.2019.02.012. Epub 2019 Feb 16.
Alkhurma hemorrhagic fever, caused by Alkhurma hemorrhagic fever virus (ALKV), is an arboviral infection which is further expanding in tropical and subtropical regions of the Western Asia. A number of Alkhurma hemorrhagic fever virus (ALKV) strains have been isolated from clinical cases representing Saudi Arabia and Egypt; however, the phylogenetic relationship of these particular isolates to those reported previously elsewhere in the world remains elusive. Based on the analysis of the envelope (E), and non-structural gene (NS3 and NS5), the phylogenetic and PASC analysis revealed the circulation of three sub-lineages (I-III) suggesting a continuous evolution. Also, the comparative genome analysis revealed the envelope gene to be a reliable genetic marker to elucidate the molecular epidemiology and genetic diversity of discrete strains of ALKV.
阿尔克姆拉出血热是由阿尔克姆拉出血热病毒（ALKV）引起的虫媒病毒性传染病，正在西亚的热带和亚热带地区进一步扩散。已从代表沙特阿拉伯和埃及的临床病例中分离出多种阿尔克姆拉出血热病毒（ALKV）毒株；然而，这些特定分离株与世界其他地方以前报告的分离株的系统发育关系仍不清楚。基于对包膜（E）和非结构基因（NS3 和 NS5）的分析，系统发育和 PASC 分析显示存在三个亚谱系（I-III）的循环，表明存在持续进化。此外，比较基因组分析显示，包膜基因是阐明离散 ALKV 株的分子流行病学和遗传多样性的可靠遗传标记。
