The Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Rhode Island Hospital, Providence, Rhode Island.
Pediatrics. 2019 Mar;143(3). doi: 10.1542/peds.2018-2001. Epub 2019 Feb 19.
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2-question screen is a valid adolescent alcohol screening tool. No studies have examined if this tool predicts future alcohol problems. We conducted a study at 16 pediatric emergency departments to determine the tool's predictive validity for alcohol misuse and alcohol use disorders (AUDs).
Participants ( = 4834) completed a baseline assessment battery. A subsample of participants completed the battery at 1, 2, and 3 years follow up.
Of the 2209 participants assigned to follow-up, 1611 (73%) completed a 1-year follow-up, 1591 (72%) completed a 2-year follow-up, and 1377 (62%) completed a 3-year follow-up. The differences in AUDs between baseline NIAAA screen nondrinkers and lower-risk drinkers were statistically significant at 1 year ( = .0002), 2 years ( <.0001), and 3 years ( = .0005), as were the differences between moderate- and highest-risk drinkers at 1 and 2 years ( < .0001 and = .0088, respectively) but not at 3 years ( = .0758). The best combined score for sensitivity (86.2% at 1 year, 75.6% at 2 years, and 60.0% at 3 years) and specificity (78.1% at 1 year, 79.2% at 2 years, and 80.0% at 3 years) was achieved by using "lower risk" and higher as a cutoff for the prediction of a diagnosis.
The NIAAA 2-question screen can accurately characterize adolescent risk for future AUDs. Future studies are needed to determine optimaluse of the screen.
国家酒精滥用与酒精中毒研究所(NIAAA)的两问筛查是一种有效的青少年酒精筛查工具。尚无研究探讨该工具是否能预测未来的酒精问题。我们在 16 家儿科急诊室开展了一项研究,以确定该工具对酒精使用障碍(AUD)的预测准确性。
参与者(n=4834)完成了基线评估工具包。部分参与者在 1、2 和 3 年的随访时完成了该工具包。
在 2209 名被分配到随访的参与者中,有 1611 名(73%)完成了 1 年随访,1591 名(72%)完成了 2 年随访,1377 名(62%)完成了 3 年随访。在 1 年(P<.0002)、2 年(P<.0001)和 3 年(P=.0005)时,基线 NIAAA 筛查不饮酒者和低风险饮酒者之间的 AUD 差异具有统计学意义,1 年和 2 年时,中风险和高风险饮酒者之间的差异也具有统计学意义(分别为 P<.0001 和 P=.0088),但 3 年时无差异(P=.0758)。敏感性(1 年时为 86.2%,2 年时为 75.6%,3 年时为 60.0%)和特异性(1 年时为 78.1%,2 年时为 79.2%,3 年时为 80.0%)的最佳综合评分是通过使用“低风险”和高风险作为预测 AUD 诊断的切点而获得的。
NIAAA 两问筛查能够准确描述青少年未来 AUD 的风险。需要进一步研究来确定该筛查的最佳使用方法。