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从蜂斗菜中分离得到的新托品类吡咯里西啶生物碱。

New otonecine-type pyrrolizidine alkaloid from Petasites japonicus.

机构信息

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.

RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

出版信息

J Nat Med. 2019 Jun;73(3):602-607. doi: 10.1007/s11418-019-01285-9. Epub 2019 Feb 19.

Abstract

One new otonecine-type pyrrolizidine alkaloid secopetasitenine (1), along with petasitenine (fukinotoxine, 2), neopetasitenine (3), and senkirkine (4), was isolated from the whole plant of Petasites japonicus. The structure of 1 was determined by spectroscopic analyses and chemical conversion from the known alkaloid petasitenine (2).

摘要

从日本白头翁全草中分离得到一个新的奥替宁型吡咯里西啶生物碱 secopetasitenine(1),以及 petasitenine(fukinotoxine,2)、neopetasitenine(3)和 senkirkine(4)。通过光谱分析和从已知生物碱 petasitenine(2)的化学转化确定了 1 的结构。

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