Samadi Sara, Mehramiz Mehrane, Kelesidis Theodoros, Mobarhan Majid Ghayour, Sahebkar Amir Hosein, Esmaily Habibollah, Moohebati Mohsen, Farjami Zahra, Ferns Gordon A, Mohammadpour Amir Hooshang, Avan Amir
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Sep;234(9):16168-16177. doi: 10.1002/jcp.28276. Epub 2019 Feb 19.
High-density lipoprotein (HDL) function rather than level may better predict cardiovascular disease (CVD). However, the contribution of the impaired antioxidant function of HDL that is associated with increased HDL lipid peroxidation (HDLox) to the development of clinical CVD remains unclear. We have investigated the association between serum HDLox with incident CVD outcomes in Mashhad cohort. Three-hundred and thirty individuals who had a median follow-up period of 7 years were recruited as part of the cohort. The primary end point was cardiovascular event, including myocardial infarction, stable angina, unstable angina, or coronary revascularization. In both univariate/multivariate analyses adjusted for traditional CVD risk factors, HDLox was an independent risk factor for CVD (odds ratio, 1.62; 95% confidence interval, 1.41-1.86; p < 0.001). For every increase in HDLox by 0.1 unit, there was an increase in CVD risk by 1.62-fold. In an adjusted analysis, there was a >2.5-fold increase in cardiovascular risk in individuals with HDLox higher than cutoff point of 1.06 compared to those with lower scores, suggesting HDLox > 1.06 is related to the impaired HDL oxidant function and in turn exposed to elevated risk of CVD outcomes (hazard ratio, 2.72; 95% CI, 1.88-3.94). Higher HDLox is a surrogate measure of reduced HDL antioxidant function that positively associated with cardiovascular events in a population-based cohort.
高密度脂蛋白（HDL）的功能而非水平可能能更好地预测心血管疾病（CVD）。然而，与HDL脂质过氧化增加（HDLox）相关的HDL抗氧化功能受损对临床CVD发生发展的影响仍不明确。我们在马什哈德队列中研究了血清HDLox与CVD发病结局之间的关联。该队列纳入了330名个体，中位随访期为7年。主要终点是心血管事件，包括心肌梗死、稳定型心绞痛、不稳定型心绞痛或冠状动脉血运重建。在针对传统CVD危险因素进行调整的单变量/多变量分析中，HDLox都是CVD的独立危险因素（优势比，1.62；95%置信区间，1.41 - 1.86；p < 0.001）。HDLox每增加0.1个单位，CVD风险增加1.62倍。在调整分析中，HDLox高于1.06临界值的个体与HDLox得分较低的个体相比，心血管风险增加超过2.5倍，这表明HDLox > 1.06与HDL氧化功能受损相关，进而使CVD结局风险升高（风险比，2.72；95%置信区间，1.88 - 3.94）。较高的HDLox是HDL抗氧化功能降低的替代指标，在基于人群的队列中与心血管事件呈正相关。
