Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Lipids Health Dis. 2020 Mar 16;19(1):42. doi: 10.1186/s12944-020-01204-y.
Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran.
This prospective cohort study comprised a population of 8698 men and women aged 35-65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence.
After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19-2; P-value< 0.01; HR: 1.53; 95% CI: 1.18-1.98; P < 0.01; HR: 1.57; 95% CI: 1.27-2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12-6.57; P-value< 0.05).
In the present study, TC baseline level was significantly associated with the risk of MI among men.
血脂异常可定义为血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）水平升高，或血清高密度脂蛋白胆固醇（HDL-C）浓度降低。血脂异常是心血管疾病（CVD）的既定危险因素。我们旨在调查伊朗东北部马什哈德人群样本中血脂异常与 CVD 事件之间的关联。
这项前瞻性队列研究包括 8698 名年龄在 35-65 岁的男性和女性，他们是从马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究中招募的。通过全面的问卷和实验室及临床评估，收集了社会经济和人口统计学状况、人体测量参数、实验室评估、生活方式因素和病史等信息。Cox 回归模型和 95%置信区间（CI）用于评估血脂异常及其成分与 CVD 发生率的关系。
在 6 年的随访后，研究人群中发现了 233 例 CVD（包括 119 例不稳定型心绞痛[US]、74 例稳定型心绞痛[SA]和 40 例心肌梗死[MI]）。未经调整的基线血清 LDL-C、TC 和 TG 水平与整个人群的总 CVD 事件风险呈正相关（HR：1.54，95%CI：1.19-2；P 值<0.01；HR：1.53；95%CI：1.18-1.98；P<0.01；HR：1.57；95%CI：1.27-2.03；P<0.01）。然而，在调整混杂因素（年龄、体重指数[BMI]、CVD 家族史、吸烟状况[非吸烟者、前吸烟者和当前吸烟者]、降脂药物治疗、抗高血压药物治疗、高血压、健康饮食指数[HEI]、总能量摄入和糖尿病的存在）后，仅在男性中 TC 与 MI 风险之间存在显著的直接关联（HR：2.71；95%CI：1.12-6.57；P 值<0.05）。
在本研究中，TC 基线水平与男性 MI 风险显著相关。
