马什哈德研究人群的血脂异常与心血管疾病风险。
Dyslipidemia and cardiovascular disease risk among the MASHAD study population.
机构信息
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Lipids Health Dis. 2020 Mar 16;19(1):42. doi: 10.1186/s12944-020-01204-y.
INTRODUCTION
Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran.
MATERIAL AND METHODS
This prospective cohort study comprised a population of 8698 men and women aged 35-65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence.
RESULTS
After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19-2; P-value< 0.01; HR: 1.53; 95% CI: 1.18-1.98; P < 0.01; HR: 1.57; 95% CI: 1.27-2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12-6.57; P-value< 0.05).
CONCLUSION
In the present study, TC baseline level was significantly associated with the risk of MI among men.
简介
血脂异常可定义为血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）水平升高，或血清高密度脂蛋白胆固醇（HDL-C）浓度降低。血脂异常是心血管疾病（CVD）的既定危险因素。我们旨在调查伊朗东北部马什哈德人群样本中血脂异常与 CVD 事件之间的关联。
材料和方法
这项前瞻性队列研究包括 8698 名年龄在 35-65 岁的男性和女性，他们是从马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究中招募的。通过全面的问卷和实验室及临床评估，收集了社会经济和人口统计学状况、人体测量参数、实验室评估、生活方式因素和病史等信息。Cox 回归模型和 95%置信区间（CI）用于评估血脂异常及其成分与 CVD 发生率的关系。
结果
在 6 年的随访后，研究人群中发现了 233 例 CVD（包括 119 例不稳定型心绞痛[US]、74 例稳定型心绞痛[SA]和 40 例心肌梗死[MI]）。未经调整的基线血清 LDL-C、TC 和 TG 水平与整个人群的总 CVD 事件风险呈正相关（HR：1.54，95%CI：1.19-2；P 值<0.01；HR：1.53；95%CI：1.18-1.98；P<0.01；HR：1.57；95%CI：1.27-2.03；P<0.01）。然而，在调整混杂因素（年龄、体重指数[BMI]、CVD 家族史、吸烟状况[非吸烟者、前吸烟者和当前吸烟者]、降脂药物治疗、抗高血压药物治疗、高血压、健康饮食指数[HEI]、总能量摄入和糖尿病的存在）后，仅在男性中 TC 与 MI 风险之间存在显著的直接关联（HR：2.71；95%CI：1.12-6.57；P 值<0.05）。
结论
在本研究中，TC 基线水平与男性 MI 风险显著相关。
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