a Key Laboratory for Petrochemical and Refinery Technologies , Vietnam Institute of Industrial Chemistry , Hanoi , Vietnam.
J Microencapsul. 2019 Jan;36(1):53-61. doi: 10.1080/02652048.2019.1585983. Epub 2019 Mar 26.
Tagitinin C, a sesquiterpene lactone compound from is known to have various bioactivities including anticancer effects. The disadvantages of tagitinin C which make its therapeutic application limited are low water solubility and poor stability. In this work, we encapsulated tagitinin C in the form of liposomal nanoparticles to overcome its limitations and evaluated its anticancer activity. Liposomes were prepared using phosphatidylcholine, tween 80 and with/without pectin. Tagitinin C liposomes exhibited small sizes, a range of 252-311 nm, and negative surface charges. Liposomes coated by pectin resulted in a slightly slower release rate than pectin-uncoated liposomes. The cytotoxicity of tagitinin C in pectin-coated liposomes was more pronounced than that in liposomes without pectin. Tagitinin C in liposomes showed significantly increased toxicity against human lung cancer cells LU-1 in comparison with DMSO-tagitinin C. Therefore, tagitinin C liposomes demonstrate significant potential as delivery systems for cancer therapy.
惕斯他宁 C 是一种倍半萜内酯化合物，具有多种生物活性，包括抗癌作用。惕斯他宁 C 的水溶性低、稳定性差等缺点使其治疗应用受到限制。在这项工作中，我们将惕斯他宁 C 包封成脂质体纳米粒，以克服其局限性，并评估其抗癌活性。脂质体由磷脂酰胆碱、吐温 80 以及有/无果胶制备而成。惕斯他宁 C 脂质体的粒径较小，范围为 252-311nm，并带有负电荷。包被果胶的脂质体的释放速度比未包被果胶的脂质体略慢。在有果胶的脂质体中，惕斯他宁 C 的细胞毒性比没有果胶的脂质体更明显。与 DMSO-惕斯他宁 C 相比，脂质体中的惕斯他宁 C 对人肺癌细胞 LU-1 的毒性显著增加。因此，惕斯他宁 C 脂质体作为癌症治疗的给药系统具有很大的潜力。
