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霍奇金淋巴瘤、肾病综合征与棘球蚴囊肿:一种不寻常的关联及文献综述

Hodgkin's lymphoma, nephrotic syndrome, and echinococcosis cysts: an unusual association and literature review.

作者信息

Geylis Michael, Rosen Guy Beck, Danino Dana, Schreiber Ruth, Hassan Dima, Nalbandyan Karen, Nahum Amit

机构信息

a Pediatrics Department A, Soroka University Medical Center, and Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer Sheva , Israel.

b Pediatric Hematology Unit, Soroka University Medical Center, and Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer Sheva , Israel.

出版信息

Pediatr Hematol Oncol. 2019 Feb;36(1):40-45. doi: 10.1080/08880018.2019.1571541. Epub 2019 Feb 20.

Abstract

We present a 5-year-old female with minimal change nephrotic syndrome (MCNS). Within several months, she became steroid-dependent with progression of edema and ascites. Imaging studies revealed abnormal solid mass and liver cysts and she was diagnosed with both abdominal Hodgkin's lymphoma (cHD) and large hepatic cystic echinococcosis (CE). Association between MCNS and cHL or with CE has been described in the literature in adults and rarely in the pediatric population. We report, for the first time, a simultaneous occurrence of all three: MCNS, cHL, and CE. Literature review and suggested pathophysiologic mechanisms underlying this phenomenon are presented.

摘要

我们报告一名5岁患微小病变型肾病综合征(MCNS)的女性。在几个月内,她出现激素依赖,并伴有水肿和腹水加重。影像学检查发现异常实性肿块和肝囊肿,她被诊断为腹部霍奇金淋巴瘤(cHD)和巨大肝囊性包虫病(CE)。MCNS与cHL或CE之间的关联在成人文献中有描述,但在儿科人群中很少见。我们首次报告了这三种疾病同时发生的情况:MCNS、cHL和CE。本文还进行了文献综述并提出了这一现象潜在的病理生理机制。

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