丁酸盐使巨噬细胞“针对细菌病原体进行核打击”。
Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens.
机构信息
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
出版信息
Immunity. 2019 Feb 19;50(2):275-278. doi: 10.1016/j.immuni.2019.01.015.
Butyrate is a microbial metabolite with pleiotropic effects. Schulthess et al. (2019) report that butyrate preconditioning of macrophages enhances their anti-bacterial preparedness by inducing anti-microbial proteins that restrict bacterial growth. This study augments understanding of how microbial metabolites shape host defense.
丁酸盐是一种具有多种效应的微生物代谢产物。Schulthess 等人（2019 年）报告称，丁酸盐预处理巨噬细胞可通过诱导限制细菌生长的抗菌蛋白来增强其抗菌准备状态。这项研究增进了人们对微生物代谢产物如何塑造宿主防御的理解。
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