Foreman J C
Department of Pharmacology, University College London, UK.
Skin Pharmacol. 1988;1(2):77-83. doi: 10.1159/000210752.
There is good evidence that some vascular effects of inflammation in the skin are neurogenic and involve axon reflexes in the terminal arborizations of C-fibres containing substance P, neurokinin A and calcitonin gene-related peptide (CGRP). Substance P produces dose-related wheal and flare reactions in human skin. Neurokinin A induces wheal but little or no flare and is less potent than substance P. CGRP induces both wheal and flare but is also less potent than substance P. In addition, CGRP induces a slow-onset, intense vasodilatation in human skin which persists for several hours and is associated with leucocyte infiltration: a response which is not seen with substance P. Substance P also releases histamine from mast cells in the skin and the presence or absence of a role for histamine and mast cells in neurogenic inflammation in skin is discussed.
有充分证据表明，皮肤炎症的某些血管效应是神经源性的，涉及含P物质、神经激肽A和降钙素基因相关肽（CGRP）的C纤维终末分支中的轴突反射。P物质在人体皮肤中产生剂量相关的风团和潮红反应。神经激肽A诱导风团，但很少或不引起潮红，且效力低于P物质。CGRP诱导风团和潮红，但效力也低于P物质。此外，CGRP在人体皮肤中诱导缓慢发作的强烈血管舒张，持续数小时，并伴有白细胞浸润：P物质不会引起这种反应。P物质还从皮肤中的肥大细胞释放组胺，文中讨论了组胺和肥大细胞在皮肤神经源性炎症中是否起作用。
