Tafler R, Herbert M K, Schmidt R F, Weis K H
Institut für Anaesthesiologie, Universität Würzburg, Germany.
Agents Actions. 1993;38 Spec No:C31-4. doi: 10.1007/BF01991128.
Capsaicin applied to human skin provokes a response known as neurogenic inflammation. Neuropeptides (substance P, CGRP), released from afferent C-fiber terminals and histamine, secondarily released from mast cells, are supposed to participate in this reaction. We investigated the contribution of arachidonic acid and metabolic products to neurogenic inflammation, using a potent topically applied glucocorticoid and the corresponding vehicle. Arachidonic acid is liberated from membrane phospholipids by phospholipase A2, an enzyme that can be blocked by glucocorticoids. In 12 healthy volunteers, neurogenic inflammation was induced by capsaicin 1% on both upper forearms after 16 h of topical pretreatment with either prednicarbate or vehicle. Neurogenic inflammation was assessed by laser Doppler flowmetry and by planimetry of flare sizes. Prednicarbate significantly reduced the laser Doppler flow values inside the flare responses, as well as the flare sizes themselves. These results show that to some extent glucocorticoids reduce capsaicin-induced neurogenic inflammation.
将辣椒素涂抹于人体皮肤会引发一种称为神经源性炎症的反应。从传入C纤维终末释放的神经肽（P物质、降钙素基因相关肽）以及随后从肥大细胞释放的组胺被认为参与了这一反应。我们使用一种强效局部应用的糖皮质激素及其相应的赋形剂，研究了花生四烯酸及其代谢产物对神经源性炎症的作用。花生四烯酸通过磷脂酶A2从膜磷脂中释放出来，该酶可被糖皮质激素阻断。在12名健康志愿者中，在用泼尼卡酯或赋形剂局部预处理16小时后，双侧前臂均用1%辣椒素诱导神经源性炎症。通过激光多普勒血流仪和红斑大小的平面测量法评估神经源性炎症。泼尼卡酯显著降低了红斑反应内的激光多普勒血流值以及红斑大小本身。这些结果表明，糖皮质激素在一定程度上可减轻辣椒素诱导的神经源性炎症。
