V Setty Jyothsna, Mendiretta Priya
Professor and Head, Department of Pedodontics and Preventive Dentistry, MR Ambedkar Dental College and Hospital, Bengaluru, Karnataka, India.
Professor, Department of Pedodontics and Preventive Dentistry, MR Ambedkar Dental College and Hospital, Bengaluru, Karnataka, India.
Int J Clin Pediatr Dent. 2018 Sep-Oct;11(5):399-405. doi: 10.5005/jp-journals-10005-1547. Epub 2018 Oct 1.
To compare nitrous oxide-oxygen inhalation and low dose oral midazolam-ketamine combination for anxiolysis in the management of children aged between 3 to 10 years for dental treatment.
A comparative clinical study with equal number of subjects in both the groups evaluating efficacy of oral ketamine-midazolam combination and nitrous oxide-oxygen inhalation in children with Frankl behavior rating score 2 and ASA1.A total of 30 children were equally divided into 2 groups, oral midazolam-ketamine (MK) group which received 0.25mg/ kg midazolam with 3mg/kg ketamine in combination and the Nitrous oxide-oxygen (N) group which received nitrous oxide-oxygen inhalation. The parameters evaluated were the drug/ mask acceptance, need for the use of a physical restraint. Houpt's sedation scale, faces pain score, sedation duration, time taken to achieve the maximum sedation and adverse reactions were assessed. Student t-test was used for comparison between the groups and proportions were compared using Chi-square test.
The results found no statistically significant differences between the groups in all the parameters except for the duration of sedation and the time taken to achieve maximum sedation which were higher in oral MK group than the Nitrous-oxide oxygen inhalation group.
Both oral-midazolam and ketamine combination and nitrous oxide-oxygen inhalation sedation were found to have similar clinical success among 3 to 10-year-old children in bringing about anxiolysis during dental treatment.
Both oral ketamine-midazolam combination, nitrous oxide-oxygen inhalation are equally effective for anxiolysis in children during dental treatment. Ilasrinivasan, Setty JV, Shyamachalam, Mendiretta P. A Comparative Evaluation of the Sedative Effects of Nitrous Oxide-oxygen Inhalation and Oral Midazolam-Ketamine Combination in Children. Int J Clin Pediatr Dent., 2018;11(5):399-405.
比较氧化亚氮-氧气吸入与低剂量口服咪达唑仑-氯胺酮联合用药在3至10岁儿童牙科治疗中用于抗焦虑的效果。
一项对比临床研究，两组受试者数量相等，评估口服氯胺酮-咪达唑仑联合用药与氧化亚氮-氧气吸入对行为Frankl评分2级且美国麻醉医师协会分级为1级的儿童的疗效。总共30名儿童被平均分为2组，口服咪达唑仑-氯胺酮（MK）组接受0.25mg/kg咪达唑仑与3mg/kg氯胺酮联合用药，氧化亚氮-氧气（N）组接受氧化亚氮-氧气吸入。评估的参数包括药物/面罩接受度、使用身体约束的必要性、Houpt镇静量表、面部疼痛评分、镇静持续时间、达到最大镇静所需时间以及不良反应。采用学生t检验进行组间比较，使用卡方检验比较比例。
结果发现，除镇静持续时间和达到最大镇静所需时间外，两组在所有参数上均无统计学显著差异，口服MK组的这两项指标高于氧化亚氮-氧气吸入组。
在3至10岁儿童牙科治疗中，口服咪达唑仑和氯胺酮联合用药与氧化亚氮-氧气吸入镇静在实现抗焦虑方面具有相似的临床成功率。
口服氯胺酮-咪达唑仑联合用药和氧化亚氮-氧气吸入在儿童牙科治疗抗焦虑方面同样有效。伊拉斯里尼瓦桑、塞蒂·JV、夏马查拉姆、门迪雷塔·P。氧化亚氮-氧气吸入与口服咪达唑仑-氯胺酮联合用药对儿童镇静效果的比较评估。《国际临床儿科牙科学杂志》，2018年；11(5):399 - 405。
