Hu Zhao, Tang Lu, Xu Hui-Lan
Dept. of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Iran J Public Health. 2018 Dec;47(12):1785-1795.
Inconsistencies among studies still exist in regard to the associations between maternal vitamin D deficiency and the risk of small for gestational age.
We conducted a meta-analysis of observational studies to evaluate these associations. We searched electronic databases for literature published in PubMed, Medline, Web of Science, Embase and the Cochrane Library up to Dec 2016 using the following keywords: "vitamin D" or "cholecalciferol" or "25-OHD" or "25-hydroxyvitamin D" in combination with "small for gestational age" or "SGA" or "fetal outcome" or "pregnancy outcome".
Twelve studies involving 19,027 participants were included in this meta-analysis. Pregnant women with vitamin D deficiency (25-OHD levels<50 nmol/L) experienced an increased risk of SGA (odds ratio (OR) =1.41, 95% confidence interval (CI): 1.14, 1.75). The vitamin D concentration of the SGA group was lower than that of the non-SGA group (mean difference: -1.75 nmol/L, 95%CI: -3.23, -0.27).
Maternal vitamin D deficiency during pregnancy may be associated with an increased risk of SGA.
关于母亲维生素D缺乏与小于胎龄儿风险之间的关联，研究结果仍存在不一致。
我们对观察性研究进行了一项荟萃分析以评估这些关联。我们在电子数据库中检索截至2016年12月在PubMed、Medline、科学网、Embase和考克兰图书馆发表的文献，使用以下关键词：“维生素D”或“胆钙化醇”或“25-OHD”或“25-羟基维生素D”，并与“小于胎龄儿”或“SGA”或“胎儿结局”或“妊娠结局”组合。
本荟萃分析纳入了12项研究，涉及19027名参与者。维生素D缺乏（25-OHD水平<50 nmol/L）的孕妇发生小于胎龄儿的风险增加（优势比（OR）=1.41，95%置信区间（CI）：1.14，1.75）。小于胎龄儿组的维生素D浓度低于非小于胎龄儿组（平均差值：-1.75 nmol/L，95%CI：-3.23，-0.27）。
孕期母亲维生素D缺乏可能与小于胎龄儿风险增加有关。
