BAP1 通过在抑制溶质载体家族 7 成员 11（SLC7A11）时诱导铁死亡来抑制肿瘤发展。
BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression.
作者信息
Zhang Yilei, Zhuang Li, Gan Boyi
机构信息
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Mol Cell Oncol. 2018 Nov 13;6(1):1536845. doi: 10.1080/23723556.2018.1536845. eCollection 2019.
Abstract
The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.
摘要
肿瘤抑制因子BRCA1相关蛋白1（BAP1）是一种去泛素化酶，可去除组蛋白2A的泛素化修饰。BAP1如何抑制肿瘤发展仍不清楚。我们最近的研究确定胱氨酸转运体溶质载体家族7成员11（SLC7A11）是BAP1的关键靶点，并表明BAP1通过抑制SLC7A11的表达促进铁死亡（一种非凋亡性细胞死亡），从而实现肿瘤抑制。
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BAP1 links metabolic regulation of ferroptosis to tumour suppression.BAP1 将铁死亡代谢调控与肿瘤抑制联系起来。
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