Zhang Yilei, Zhuang Li, Gan Boyi
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mol Cell Oncol. 2018 Nov 13;6(1):1536845. doi: 10.1080/23723556.2018.1536845. eCollection 2019.
The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.
肿瘤抑制因子BRCA1相关蛋白1（BAP1）是一种去泛素化酶，可去除组蛋白2A的泛素化修饰。BAP1如何抑制肿瘤发展仍不清楚。我们最近的研究确定胱氨酸转运体溶质载体家族7成员11（SLC7A11）是BAP1的关键靶点，并表明BAP1通过抑制SLC7A11的表达促进铁死亡（一种非凋亡性细胞死亡），从而实现肿瘤抑制。
