• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MOTS-c: an equal opportunity insulin sensitizer.

作者信息

Kim Su-Jeong, Miller Brendan, Kumagai Hiroshi, Yen Kelvin, Cohen Pinchas

机构信息

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089-0191, USA.

出版信息

J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20.

DOI:10.1007/s00109-019-01758-0
PMID:30788534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6462348/
Abstract
摘要

相似文献

1
MOTS-c: an equal opportunity insulin sensitizer.运动诱导的循环微小RNA-122-5p：一种平等机会的胰岛素增敏剂。
J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20.
2
MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.MOTS-c 肽调节脂肪组织平衡以预防去卵巢诱导的代谢功能障碍。
J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019 Feb 6.
3
Tipping the metabolic scales towards increased longevity in mammals.促使哺乳动物代谢平衡向延长寿命方向倾斜。
Nat Cell Biol. 2015 Mar;17(3):196-203. doi: 10.1038/ncb3107.
4
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.MOTS-c：一种调节肌肉和脂肪代谢的新型线粒体衍生肽。
Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20.
5
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.线粒体衍生肽MOTS-c是血浆代谢物的调节剂，可增强胰岛素敏感性。
Physiol Rep. 2019 Jul;7(13):e14171. doi: 10.14814/phy2.14171.
6
MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway.MOTS-c 通过 AMPK 信号通路与运动干预协同作用，调节 PGC-1α 的表达，减轻胰岛素抵抗，增强小鼠的葡萄糖代谢。
Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166126. doi: 10.1016/j.bbadis.2021.166126. Epub 2021 Mar 13.
7
Mitochondria in metabolic disease: getting clues from proteomic studies.代谢性疾病中的线粒体：从蛋白质组学研究中获取线索
Proteomics. 2014 Mar;14(4-5):452-66. doi: 10.1002/pmic.201300376.
8
Mitofusion is required for MOTS-c induced GLUT4 translocation.线粒体融合对于 MOTS-c 诱导的 GLUT4 易位是必需的。
Sci Rep. 2021 Jul 12;11(1):14291. doi: 10.1038/s41598-021-93735-2.
9
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.线粒体衍生肽MOTS-c可促进代谢稳态，减轻肥胖和胰岛素抵抗。
Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009.
10
Mitochondrially derived peptides as novel regulators of metabolism.线粒体衍生肽作为代谢的新型调节剂。
J Physiol. 2017 Nov 1;595(21):6613-6621. doi: 10.1113/JP274472. Epub 2017 Jul 18.

引用本文的文献

1
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.线粒体衍生的微小蛋白MOTS-c通过抑制脂质浸润减轻固定诱导的骨骼肌萎缩。
Am J Physiol Endocrinol Metab. 2024 Mar 1;326(3):E207-E214. doi: 10.1152/ajpendo.00285.2023. Epub 2024 Jan 3.
2
Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases.线粒体 DNA 的新见解：线粒体小蛋白和 mtDNA 变体调节运动表现和与年龄相关的疾病。
Genes (Basel). 2023 Jan 21;14(2):286. doi: 10.3390/genes14020286.
3
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.

本文引用的文献

1
MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.MOTS-c 肽调节脂肪组织平衡以预防去卵巢诱导的代谢功能障碍。
J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019 Feb 6.
2
MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway.MOTS-c 通过 TGF-β/Smad 通路促进骨髓间充质干细胞的成骨分化来改善骨质疏松症。
Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7156-7163. doi: 10.26355/eurrev_201811_16247.
3
Small, but mighty? Searching for human microproteins and their potential for understanding health and disease.
线粒体衍生肽 MOTS-c：与应激、代谢和衰老相关的作用和机制。
J Transl Med. 2023 Jan 20;21(1):36. doi: 10.1186/s12967-023-03885-2.
4
Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.循环线粒体衍生肽的种族差异可能导致前列腺癌健康差距。
Prostate. 2022 Sep;82(13):1248-1257. doi: 10.1002/pros.24398. Epub 2022 Jul 5.
5
Mitochondria-derived peptides in aging and healthspan.线粒体衍生肽与衰老和健康寿命。
J Clin Invest. 2022 May 2;132(9). doi: 10.1172/JCI158449.
6
The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets.线粒体衍生肽在心血管疾病中的作用及其作为治疗靶点的潜力。
Int J Mol Sci. 2021 Aug 16;22(16):8770. doi: 10.3390/ijms22168770.
7
Mitofusion is required for MOTS-c induced GLUT4 translocation.线粒体融合对于 MOTS-c 诱导的 GLUT4 易位是必需的。
Sci Rep. 2021 Jul 12;11(1):14291. doi: 10.1038/s41598-021-93735-2.
8
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.线粒体衍生肽人促胰岛素是寿命和健康寿命的调节剂。
Aging (Albany NY). 2020 Jun 23;12(12):11185-11199. doi: 10.18632/aging.103534.
9
Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.健康老年男性骨骼肌中线粒体衍生肽 MOTS-c 的表达增加与肌纤维组成有关。
Aging (Albany NY). 2020 Mar 17;12(6):5244-5258. doi: 10.18632/aging.102944.
10
Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation.线粒体衍生肽 MOTS-c 增加脂肪的产热激活以促进冷适应。
Int J Mol Sci. 2019 May 17;20(10):2456. doi: 10.3390/ijms20102456.
小而强大？探寻人类微小蛋白质及其在理解健康与疾病方面的潜力。
Expert Rev Proteomics. 2018 Dec;15(12):963-965. doi: 10.1080/14789450.2018.1547194. Epub 2018 Nov 15.
4
Cardiovascular Implications of the Menopause Transition: Endogenous Sex Hormones and Vasomotor Symptoms.绝经过渡期的心血管影响：内源性性激素与血管舒缩症状。
Obstet Gynecol Clin North Am. 2018 Dec;45(4):641-661. doi: 10.1016/j.ogc.2018.07.006. Epub 2018 Oct 25.
5
Cardiorespiratory Fitness, Adiposity, and Heart Rate Variability: The Coronary Artery Risk Development in Young Adults Study.心肺适能、肥胖与心率变异性：年轻人冠状动脉风险发展研究。
Med Sci Sports Exerc. 2019 Mar;51(3):509-514. doi: 10.1249/MSS.0000000000001796.
6
Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives.更年期与非酒精性脂肪性肝病：治疗视角的综述。
Curr Vasc Pharmacol. 2019;17(6):546-555. doi: 10.2174/1570161116666180711121949.
7
Diabetes in Menopause: Risks and Management.更年期与糖尿病：风险与管理。
Curr Vasc Pharmacol. 2019;17(6):556-563. doi: 10.2174/1570161116666180625124405.
8
Mitochondrial peptides modulate mitochondrial function during cellular senescence.线粒体肽在细胞衰老过程中调节线粒体功能。
Aging (Albany NY). 2018 Jun 10;10(6):1239-1256. doi: 10.18632/aging.101463.
9
Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.肥胖男童和青少年的循环MOTS-c水平降低，且与胰岛素抵抗相关。
Pediatr Diabetes. 2018 Apr 25. doi: 10.1111/pedi.12685.
10
Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals.血浆 MOTS-c 水平与瘦人而非肥胖人群的胰岛素敏感性相关。
J Investig Med. 2018 Aug;66(6):1019-1022. doi: 10.1136/jim-2017-000681. Epub 2018 Mar 27.