Department of Dermatology, University Hospital of Heraklion, 71110, Crete, Greece.
Faculty of Social Sciences, Hellenic Open University, Patra, Greece.
Arch Dermatol Res. 2019 Apr;311(3):221-230. doi: 10.1007/s00403-019-01900-5. Epub 2019 Feb 20.
Pruritic dermatosis is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and the health-related quality of life (HRQoL) in patients with pruritic dermatoses and (2) to compare the results with data on socio-demographic data, and clinical features/symptoms of the patients. One hundred and three patients with pruritic dermatosis had participated in a non-interventional, cross-sectional study. Socio-demographic data, clinical features/symptoms, a health-related quality of life (HRQoL)-based and a dermatology-specific instrument (SF-6D and DLQI, respectively), and two utility indicators such as rating scale (RS) and time-trade-off (TTO) as well as willingness to pay (WTP) were recorded. In our study, there was a significant correlation between DLQI scores and WTP (p < 0.001). Time-trade-off (TTO) was also statistically correlated with SF-6D (p = 0.001). Regression models showed that daily duration and pruritus intensity were associated with lower HRQoL. Furthermore, WTP was the only measure revealing demographic and socio-economic characteristics such as age, education level, family status and income as predicting factors. No significant differences between groups of varying skin diseases were observed. HRQoL and WTP proved to be valid tools to assess the burden of disease in patients with pruritic dermatosis. However, further research with a larger number of patients is needed to validate the present findings.
瘙痒性皮肤病是一种常见且负担沉重的疾病。本研究的目的是：（1）评估瘙痒性皮肤病患者的支付意愿（WTP）和健康相关生活质量（HRQoL）；（2）并将结果与患者的社会人口统计学数据和临床特征/症状进行比较。103 名瘙痒性皮肤病患者参与了一项非干预性、横断面研究。记录了社会人口统计学数据、临床特征/症状、基于健康相关生活质量（HRQoL）和皮肤病特异性的工具（SF-6D 和 DLQI）、以及两个效用指标（如评分量表（RS）和时间权衡（TTO）以及支付意愿（WTP）。在我们的研究中，DLQI 评分与 WTP 之间存在显著相关性（p < 0.001）。TTO 与 SF-6D 也呈统计学相关（p = 0.001）。回归模型表明，每日持续时间和瘙痒强度与较低的 HRQoL 相关。此外，WTP 是唯一能够揭示年龄、教育程度、家庭状况和收入等人口统计学和社会经济特征的预测因素的衡量标准。不同皮肤病组之间没有观察到显著差异。HRQoL 和 WTP 被证明是评估瘙痒性皮肤病患者疾病负担的有效工具。然而，需要进一步研究更多患者来验证目前的发现。
