Borshchev Yu Yu, Sinitsa A V, Zakharchenko M M, Borshchev V Yu, Burovenko I Yu, Galagudza M M
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med. 2019 Feb;166(4):440-443. doi: 10.1007/s10517-019-04368-5. Epub 2019 Feb 20.
Changes in morphofunctional parameters of the isolated heart subjected to global ischemia-reperfusion were studied in SPF Wistar rats with antibiotic-induced dysbiosis (AID) treated with lyophilized yeast Saccharomyces boulardii and inactivated probiotic bacteria Lactobacillus reuteri KR2017. In contrast to S. boulardii, correction of dysbiosis with L. reuteri KR2017 against the background of gastric hypersecretion and standard antimicrobial therapy led to an increase in fat content and a decrease in free and bound water in tissues and to a significant reduction in myocardial infarct size caused by ischemia/ reperfusion injury.
在抗生素诱导的菌群失调（AID）的无特定病原体（SPF）Wistar大鼠中，研究了接受全球缺血再灌注的离体心脏的形态功能参数变化，这些大鼠分别用冻干的布拉酵母菌和灭活的益生菌罗伊氏乳杆菌KR2017进行治疗。与布拉酵母菌相反，在胃酸分泌过多和标准抗菌治疗的背景下，用罗伊氏乳杆菌KR2017纠正菌群失调导致组织中脂肪含量增加、自由水和结合水减少，并使缺血/再灌注损伤引起的心肌梗死面积显著减小。
