Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of the Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med. 2022 Apr;172(6):676-680. doi: 10.1007/s10517-022-05455-w. Epub 2022 May 2.
The effect of probiotic therapy on the main hemodynamic parameters was studied in Wistar rats with modeled syndrome of systemic inflammatory response resulting from chemically induced colitis complicated by antibiotic-induced dysbiosis. Using a wireless telemetry monitoring system in round-the-clock mode, the mean systolic and diastolic BP, HR, and body temperature were measured over 27 days. In the group of animals receiving no probiotics, a significant decrease in feed consumption and body weight loss were observed. By the end of the experiment, BP in this group was lower by 12% and HR was higher by 10% than in the control. In animals treated with a mixture of probiotic strains Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis, all the studied parameters returned to the initial values. Thus, we demonstrated the possibility of using probiotic drugs for the treatment of acute systemic inflammatory process, which should be considered in the development of new treatment protocols in veterinary and medicine.
本研究旨在探讨益生菌疗法对全身炎症反应综合征（systemic inflammatory response syndrome, SIRS）模型大鼠主要血流动力学参数的影响。该模型由化学诱导结肠炎合并抗生素诱导的肠道菌群失调引起。采用无线遥测监测系统，在 27 天的时间内对平均收缩压、舒张压、心率（heart rate, HR）和体温进行了昼夜监测。在未接受益生菌治疗的动物组中，观察到饲料摄入量显著减少和体重减轻。实验结束时，该组的血压降低了 12%，心率升高了 10%，与对照组相比。在接受嗜酸乳杆菌和动物双歧杆菌亚种乳酸混合益生菌菌株治疗的动物中，所有研究参数均恢复到初始值。因此，我们证明了使用益生菌药物治疗急性全身炎症过程的可能性，这在兽医和医学新治疗方案的制定中应予以考虑。
