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多发性硬化症患者中的E玫瑰花结形成淋巴细胞。对玫瑰花结形成细胞的碱性蛋白刺激。

E rosette-forming lymphocytes in multiple sclerosis patients. Basic protein stimulation of rosette-forming cells.

作者信息

Offner H, Konat G, Raun N E, Clausen J

出版信息

Acta Neurol Scand. 1978 May;57(5):380-4. doi: 10.1111/j.1600-0404.1978.tb02841.x.

DOI:10.1111/j.1600-0404.1978.tb02841.x
PMID:307895
Abstract

"Total" and "active" T cells were enumerated using sheep red blood cell (SRBC) rosetting technique. The percentages of "total" and "active" T lymphocytes were not significantly different in multiple sclerosis patients as compared to other neurological disorders and/or healthy controls. However, the number of "avid" T cells binding more than three SRBC was significantly increased in MS patients. Active E rosette test has shown hypersensitization to myelin basic protein in 50% MS patients and 31% OND patients. All healthy controls studied, except one had negative response.

摘要

使用绵羊红细胞(SRBC)玫瑰花结技术对“总”T细胞和“活性”T细胞进行计数。与其他神经系统疾病和/或健康对照相比,多发性硬化症患者中“总”T淋巴细胞和“活性”T淋巴细胞的百分比无显著差异。然而,与三个以上SRBC结合的“avid”T细胞数量在MS患者中显著增加。活性E玫瑰花结试验显示,50%的MS患者和31%的其他神经系统疾病(OND)患者对髓鞘碱性蛋白过敏。除一名健康对照外,所有研究的健康对照均呈阴性反应。

相似文献

1
E rosette-forming lymphocytes in multiple sclerosis patients. Basic protein stimulation of rosette-forming cells.多发性硬化症患者中的E玫瑰花结形成淋巴细胞。对玫瑰花结形成细胞的碱性蛋白刺激。
Acta Neurol Scand. 1978 May;57(5):380-4. doi: 10.1111/j.1600-0404.1978.tb02841.x.
2
Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides.神经节苷脂和脑苷脂对多发性硬化症患者活性E花环形成淋巴细胞的刺激作用。
J Neurol Sci. 1980 Apr;46(1):101-4. doi: 10.1016/0022-510x(80)90046-5.
3
Myelin basic protein-stimulated rosette-forming T cells in multiple sclerosis.多发性硬化症中髓鞘碱性蛋白刺激的花环形成T细胞
Neurochem Res. 1978 Feb;3(1):37-48. doi: 10.1007/BF00964359.
4
Stimulation of active E-rosette forming lymphocytes by myelin basic protein and specific antigens from multiple sclerosis brains.髓磷脂碱性蛋白和来自多发性硬化症患者大脑的特异性抗原对活性E花环形成淋巴细胞的刺激作用。
J Neurol Sci. 1979 Aug;42(3):349-55. doi: 10.1016/0022-510x(79)90168-0.
5
The E-rosette test: variations in results using E from different sheep. Effect of FCS and of AET treatment.
Acta Pathol Microbiol Immunol Scand C. 1983 Dec;91(6):367-70.
6
Multi-sialo brain gangliosides are powerful stimulators of active E-rosetting lymphocytes from multiple sclerosis patients.多唾液酸脑苷脂是来自多发性硬化症患者的活性E花环形成淋巴细胞的强效刺激剂。
J Neurol Sci. 1981 Nov-Dec;52(2-3):279-87. doi: 10.1016/0022-510x(81)90011-3.
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Characterization of active T cells in CSF and blood in multiple sclerosis patients and controls.多发性硬化症患者及对照者脑脊液和血液中活性T细胞的特征分析。
Scand J Immunol. 1980;12(2):99-108. doi: 10.1111/j.1365-3083.1980.tb00046.x.
8
Heterogeneity of human T lymphocytes to bind sheep red blood cells in multiple sclerosis patients and controls.
Boll Ist Sieroter Milan. 1978 Jan 31;56(6):603-8.
9
Myelin basic protein-responsive blood T lymphocytes in patients with multiple sclerosis.
J Neurosci Res. 1985;13(3):349-55. doi: 10.1002/jnr.490130302.
10
Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.多发性硬化症、系统性红斑狼疮和类风湿性关节炎中活性E花环形成淋巴细胞的抗原刺激。
Clin Immunol Immunopathol. 1980 Jul;16(3):367-73. doi: 10.1016/0090-1229(80)90142-7.

引用本文的文献

1
On the role of sensitised T-lymphocytes in the pathogenesis of multiple sclerosis.致敏T淋巴细胞在多发性硬化症发病机制中的作用
J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):305-9. doi: 10.1136/jnnp.43.4.305.