Turner A, Cuzner M L, Davison A N, Rudge P
J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):305-9. doi: 10.1136/jnnp.43.4.305.
Peripheral blood lymphocytes from 24 out of 26 patients with clinically well-defined multiple sclerosis in remission showed sensitisation to multiple sclerosis brain extracts as assayed by enhancement of the early erythrocyte rosette test. Such an increase in the number of early rosettes was not found when the lymphocytes of multiple sclerosis patients were exposed to extracts of control brains. In contrast the sensitised cells were found in the circulation in only two of 11 patients with multiple sclerosis in acute relapse. The percentage of circulating T-lymphocytes which formed early rosettes was lower in the group of patients suffering a relapse than in patients in remission. A longitudinal study of one patient who was tested before, during and after a relapse revealed the disappearance from the blood of the sensitised T-cells during the relapse and their subsequent reappearance after recovery. Of 36 patients with other neurological diseases, two responded solely to multiple sclerosis brain, two responded to both multiple sclerosis and control brain, and three responded only to control brain. No healthy controls showed sensitisation to any brain extract.
在缓解期临床确诊为多发性硬化症的26例患者中，24例患者的外周血淋巴细胞经早期红细胞玫瑰花结试验增强检测，显示对多发性硬化症脑提取物敏感。当将多发性硬化症患者的淋巴细胞暴露于对照脑提取物时，未发现早期玫瑰花结数量有这种增加。相比之下，在11例急性复发的多发性硬化症患者中，只有2例在循环中发现了致敏细胞。复发组中形成早期玫瑰花结的循环T淋巴细胞百分比低于缓解期患者。对一名在复发前、复发期间和复发后进行检测的患者进行的纵向研究显示，复发期间致敏T细胞从血液中消失，恢复后又重新出现。在36例患有其他神经系统疾病的患者中，2例仅对多发性硬化症脑有反应，2例对多发性硬化症脑和对照脑均有反应，3例仅对对照脑有反应。没有健康对照显示对任何脑提取物敏感。
