中国农村地区5-羟色胺受体2A、色氨酸羟化酶1和色氨酸羟化酶2基因多态性与自杀未遂的关联
Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China.
作者信息
Pan Yan-Fei, Zhang Ji-Yu, Qiu Hui-Min, Yu Peng-Peng, Liu Zhen-Zhen, Liu Bao-Peng, Jia Cun-Xian
机构信息
Department of Epidemiology, School of Public Health, Shandong University and Shandong University Center for Suicide Prevention Research.
Shandong Provincial Center for Disease Control and Prevention.
出版信息
Psychiatr Genet. 2019 Jun;29(3):79-85. doi: 10.1097/YPG.0000000000000221.
OBJECTIVE
We aimed to test the association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China.
PARTICIPANTS AND METHODS
On the basis of a case-control study, we recruited 1200 pairs of participants from Shandong Province, China. The blood samples of 712 suicide attempters and 739 nonsuicide attempters were collected finally. We tested seven single nucleotide polymorphisms: rs6313 and rs6311 in HTR2A, rs4537731, rs1800532, and rs1799913 in TPH1, and rs4448731 and rs4641527 in TPH2.
RESULTS
In univariate analysis, allele C of rs4537731 was associated negatively with attempted suicide among total and male samples; however, the association was not statistically significant in multivariate analysis after adjusting for other potential confounding factors. No association between other six single nucleotide polymorphisms and attempted suicide was found in the total, male, or female samples.
CONCLUSION
This study did not support the effect of these seven serotonergic gene polymorphisms on attempted suicide in rural China.
目的
我们旨在检测中国农村地区5-羟色胺受体2A（HTR2A）、色氨酸羟化酶1（TPH1）和色氨酸羟化酶2（TPH2）基因多态性与自杀未遂之间的关联。
参与者与方法
基于一项病例对照研究，我们从中国山东省招募了1200对参与者。最终收集了712名自杀未遂者和739名非自杀未遂者的血样。我们检测了7个单核苷酸多态性：HTR2A基因中的rs6313和rs6311、TPH1基因中的rs4537731、rs1800532和rs1799913，以及TPH2基因中的rs4448731和rs4641527。
结果
在单因素分析中，rs4537731的C等位基因在全部样本和男性样本中与自杀未遂呈负相关；然而，在调整其他潜在混杂因素后的多因素分析中，该关联无统计学意义。在全部、男性或女性样本中，未发现其他6个单核苷酸多态性与自杀未遂之间存在关联。
结论
本研究不支持这7种血清素能基因多态性对中国农村地区自杀未遂的影响。
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