Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Beijing, 100050, China.
Brain Imaging Behav. 2020 Aug;14(4):1298-1308. doi: 10.1007/s11682-019-00045-3.
Previous task-fMRI studies have reported the abnormal brain activations in major depressive disorders (MDD) with suicidal behavior. However, there is no consensus of opinion on task-fMRI imaging findings of the suicidal brain. We performed a meta-analysis to integrate the results of reported studies to find the consistent task-related alteration pattern of brain activations in MDD patients with suicidal behavior, aiming to investigate brain functional alterations in association with a vulnerability to suicidal behavior. Using the SDM (Seed-based d Mapping) method, we conducted a meta-analysis of the task-fMRI studies to compare the brain activations between major depressive disorder (MDD) patients with a history of suicidal behavior (suicide attempter, ATT) and the MDD patients without suicidal behavior (non-attempters, NAT) during tasks. Our systematic search identified 7 task-fMRI studies comprising 366 individuals, i.e., 150 ATT and 216 NAT. We found that brain activation in ATT increased in the left insula, while decreased in the bilateral fusiform gyrus compared to NAT during the fMRI tasks. We found the brain activation changes in the insula and fusiform gyrus in MDD patients with a history of suicide attempt during fMRI tasks. The brain activation changes in these regions were associated with the dysfunction of emotion regulation, processing negative information and self-awareness which may increase the vulnerability of suicidal behavior in MDD patients.
先前的任务态 fMRI 研究报告了有自杀行为的重性抑郁障碍（MDD）患者的大脑异常激活。然而，对于自杀大脑的任务态 fMRI 影像学发现尚未达成共识。我们进行了一项荟萃分析，整合了已报道研究的结果，以找到 MDD 伴自杀行为患者大脑激活的一致任务相关改变模式，旨在研究与自杀行为易感性相关的大脑功能改变。使用 SDM（基于种子的 d 映射）方法，我们对任务态 fMRI 研究进行了荟萃分析，比较了有自杀行为史（自杀未遂者，ATT）和无自杀行为史（非未遂者，NAT）的 MDD 患者在任务期间的大脑激活。我们的系统搜索确定了 7 项任务态 fMRI 研究，共包括 366 人，即 150 名 ATT 和 216 名 NAT。我们发现，与 NAT 相比，ATT 在 fMRI 任务中左岛叶的激活增加，而双侧梭状回的激活减少。我们发现 MDD 患者在 fMRI 任务中有自杀未遂史时，其岛叶和梭状回的大脑激活发生变化。这些区域的大脑激活变化与情绪调节、处理负性信息和自我意识的功能障碍有关，这可能增加 MDD 患者自杀行为的易感性。
