The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Metal Disorders, Guangzhou, China.
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Metal Disorders, Guangzhou, China.
J Affect Disord. 2022 Dec 15;319:70-78. doi: 10.1016/j.jad.2022.08.122. Epub 2022 Sep 6.
The resting-state functional magnetic resonance imaging (rs-fMRI) have been used to explore functional abnormality of the brain in MDD patients with suicidal ideation (SI). However, few studies reported the variability and concordance of alterations of rs-fMRI indices in MDD with SI. In this study, we aimed to explore the variability and concordance of alterations of rs-fMRI indices in MDD with SI.
A sliding window analysis was performed among 36 MDD patients with SI, 66 MDD patients without SI (NSI), and 50 healthy controls (HCs). Furthermore, the correlation between voxel-wise concordance and cognitive function was examined in the SI group.
The SI group had a lower dynamics degree centrality (dDC) value than the NSI group in left inferior occipital gyrus, and a lower voxel mirrored homotopic connectivity (dVMHC) value than the NSI group in the right and left inferior occipital gyrus. The mean values of volume wise concordance of HCs group shown higher than SI group and NSI group. SI group revealed decreased voxel-wise concordance in right cerebellum, left fusiform gyrus, left lingual gyrus, right middle temporal gyrus, left postcentral gyrus, and right supplementary motor area compared to NSI group. Moreover, the voxel-wise concordance of left middle occipital gyrus was negatively correlated with verbal learning and memory and working memory in the SI group.
This is a cross-sectional analysis, limiting causal inferences.
The abnormal voxel-wise concordance of left middle occipital gyrus could be useful in understanding the pathophysiology of MDD patients with SI.
静息态功能磁共振成像（rs-fMRI）已被用于探索有自杀意念（SI）的 MDD 患者大脑的功能异常。然而，很少有研究报告 MDD 伴 SI 患者 rs-fMRI 指标改变的可变性和一致性。在本研究中，我们旨在探讨 MDD 伴 SI 患者 rs-fMRI 指标改变的可变性和一致性。
对 36 例有 SI 的 MDD 患者、66 例无 SI（NSI）的 MDD 患者和 50 名健康对照（HCs）进行滑动窗口分析。此外，在 SI 组中还检查了体素一致性与认知功能之间的相关性。
与 NSI 组相比，SI 组在左侧枕下回的动态度中心度（dDC）值较低，在右侧和左侧枕下回的体素镜像同型连接（dVMHC）值较低。HCs 组的均值一致性值高于 SI 组和 NSI 组。与 NSI 组相比，SI 组在右侧小脑、左侧梭状回、左侧舌回、右侧颞中回、左侧中央后回和右侧辅助运动区的体素一致性降低。此外，左侧中枕回的体素一致性与 SI 组的言语学习和记忆以及工作记忆呈负相关。
这是一项横断面分析，限制了因果推断。
左侧中枕回异常的体素一致性可能有助于理解有 SI 的 MDD 患者的病理生理学。
