Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):839-848. doi: 10.1016/j.bbamcr.2019.02.009. Epub 2019 Feb 18.
All organisms end with their death, and many parts of cells die through intrinsic suicide machineries in response to diverse stimuli. These intrinsic cell death pathways are often termed as programmed cell deaths (PCDs), and are critical for organism development, tissue homeostasis and various diseases. Recent evidence has revealed that most of PCDs involve a tumor suppressor p53 and components of the intra-mitochondria. Furthermore, the movement and positioning of p53 in cells affect the induction of each PCD pathway. Here we provide a comprehensive review on p53-related PCD mechanisms via the mitochondria, namely classical apoptosis, non-classical apoptosis, autophagic cell death, ferroptosis, necroptosis. In addition, we discuss the roles of p53 in each PCD pathway by focusing its altered intracellular localization in response to diverse cellular stresses.
所有生物最终都会死亡，许多细胞的部分也会因响应各种刺激而通过内在的自杀机制死亡。这些内在的细胞死亡途径通常被称为程序性细胞死亡（PCD），对于生物体的发育、组织平衡和各种疾病都至关重要。最近的证据表明，大多数 PCD 涉及肿瘤抑制因子 p53 和线粒体内部的成分。此外，p53 在细胞中的运动和定位会影响每种 PCD 途径的诱导。在这里，我们通过线粒体综述了与 p53 相关的 PCD 机制，即经典凋亡、非经典凋亡、自噬细胞死亡、铁死亡、坏死性凋亡。此外，我们还通过关注 p53 在应对各种细胞应激时改变的细胞内定位，讨论了其在每种 PCD 途径中的作用。
