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谷胱甘肽-S-转移酶 mu-1 缺失基因型增加了木烟诱导的气道炎症。

The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation.

机构信息

Division of Allergy, Immunology, & Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC; Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.

Duke University School of Medicine, Durham, NC.

出版信息

J Allergy Clin Immunol. 2019 Jun;143(6):2299-2302.e3. doi: 10.1016/j.jaci.2019.02.006. Epub 2019 Feb 18.

DOI:10.1016/j.jaci.2019.02.006
PMID:30790595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6556420/
Abstract

A 2-hour exposure to 500 μg/m wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant.

摘要

暴露于 500μg/m 的木柴烟雾颗粒 2 小时可引起人类志愿者的中性粒细胞性气道炎症，GSTM1 缺失基因型与对这种污染物的更大炎症反应相关。

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