Hellebuyck H, Maes M, Suy E
Psychiatrisch Centrum Sint-Jozef, Bilzen, Belgium.
Acta Psychiatr Belg. 1988;88(5-6):378-86.
A review is made on the repeated dexamethasone suppression test (DST) in patients with a major depression. In those patients treated with conventional antidepressants the gradual normalization of the DST results is significantly correlated with the evolution of the clinical picture as measured with the Hamilton Depression Rating Scale. Normalization of the DST precedes symptomatic improvement and can be used as a predictor of good clinical outcome. Persistent dexamethasone non-suppression after treatment and complete clinical recovery predicts early clinical relapse. Patients with recurrent depression tend to have consistency of their response to dexamethasone over multiple depressive episodes.
对重度抑郁症患者重复地塞米松抑制试验（DST）进行了综述。在接受传统抗抑郁药治疗的患者中，DST结果逐渐恢复正常与汉密尔顿抑郁量表所衡量的临床症状演变显著相关。DST恢复正常先于症状改善，可作为临床良好预后的预测指标。治疗后持续地塞米松不抑制且临床完全恢复预示着早期临床复发。复发性抑郁症患者在多次抑郁发作中对地塞米松的反应往往具有一致性。
