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Alcohol-related liver disease (ALD): current perspectives on pathogenesis, therapeutic strategies, and animal models.酒精性肝病（ALD）：关于发病机制、治疗策略及动物模型的当前观点
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本文引用的文献

1
Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials.皮质类固醇与己酮可可碱或安慰剂相比可降低重症酒精性肝炎患者 28 天内的死亡率：来自对照试验的个体数据的荟萃分析。
Gastroenterology. 2018 Aug;155(2):458-468.e8. doi: 10.1053/j.gastro.2018.05.011. Epub 2018 May 5.
2
Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice.调节肠道胆汁酸/法尼醇 X 受体/成纤维细胞生长因子 15 轴可改善小鼠的酒精性肝病。
Hepatology. 2018 Jun;67(6):2150-2166. doi: 10.1002/hep.29676. Epub 2018 Apr 16.
3
NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation.中性粒细胞中 NADPH 氧化酶耗竭与肝硬化患者，以及通过 Toll 样受体 7/8 激活的恢复。
Gut. 2018 Aug;67(8):1505-1516. doi: 10.1136/gutjnl-2016-313443. Epub 2017 Jun 10.
4
Novel treatment options for portal hypertension.门静脉高压症的新型治疗选择。
Gastroenterol Rep (Oxf). 2017 May;5(2):90-103. doi: 10.1093/gastro/gox011. Epub 2017 Apr 18.
5
EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis.EASL 临床实践指南：原发性胆汁性胆管炎患者的诊断和管理。
J Hepatol. 2017 Jul;67(1):145-172. doi: 10.1016/j.jhep.2017.03.022. Epub 2017 Apr 18.
6
In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA.在重症酒精性肝炎患者中，泼尼松龙会增加感染易感性和感染相关死亡率，并与循环中细菌DNA的高浓度有关。
Gastroenterology. 2017 Apr;152(5):1068-1077.e4. doi: 10.1053/j.gastro.2016.12.019. Epub 2016 Dec 30.
7
Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.单核细胞氧化爆发缺陷预示酒精性肝炎患者发生感染，且与NADPH氧化酶表达降低有关。
Gut. 2017 Mar;66(3):519-529. doi: 10.1136/gutjnl-2015-310378. Epub 2016 Feb 9.
8
Intensive Enteral Nutrition Is Ineffective for Patients With Severe Alcoholic Hepatitis Treated With Corticosteroids.强化肠内营养对接受皮质类固醇治疗的重症酒精性肝炎患者无效。
Gastroenterology. 2016 Apr;150(4):903-10.e8. doi: 10.1053/j.gastro.2015.12.038. Epub 2016 Jan 5.
9
Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease.肠道微生物群有助于个体对酒精性肝病的易感性。
Gut. 2016 May;65(5):830-9. doi: 10.1136/gutjnl-2015-310585. Epub 2015 Dec 7.
10
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.美他多辛可提高重症酒精性肝炎患者3个月和6个月的生存率。
World J Gastroenterol. 2015 Apr 28;21(16):4975-85. doi: 10.3748/wjg.v21.i16.4975.

The future of therapy for alcoholic hepatitis - Beyond corticosteroids.

作者信息

Vergis Nikhil, Atkinson Stephen R, Thursz Mark R

机构信息

Department of Hepatology, Imperial College, London, United Kingdom.

Department of Hepatology, Imperial College, London, United Kingdom.

出版信息

J Hepatol. 2019 Apr;70(4):785-787. doi: 10.1016/j.jhep.2019.01.016. Epub 2019 Feb 18.

DOI:10.1016/j.jhep.2019.01.016
PMID:30791978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6420340/
Abstract
摘要