美国退伍军人的加速 DNA 甲基化衰老：来自国家退伍军人健康与复原力研究的结果。
Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.
机构信息
Department of Psychology (AJFT), St. John's University, Queens, NY.
Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT.
出版信息
Am J Geriatr Psychiatry. 2019 May;27(5):528-532. doi: 10.1016/j.jagp.2019.01.001. Epub 2019 Jan 7.
OBJECTIVE
The aim of this study was to identify how a broad range of sociodemographic, military, health, and psychosocial factors relate to accelerated DNA methylation aging (Δ) in a large, contemporary, nationally representative sample of male U.S. veterans.
METHODS
Data were analyzed from a sample of U.S. male European-American veterans who participated in the National Health and Resilience in Veterans Study (N = 1,135).
RESULTS
Psychosocial factors of lifetime trauma burden, child sexual trauma, and negative beliefs about aging were independently associated with Δ. Three health variables-diabetes, hypertension, and body mass index-emerged as additional correlates of Δ.
CONCLUSION
Results of the study build on prior work demonstrating associations between accelerated DNA methylation aging and traumatic stress, highlighting a role for child sexual abuse in particular. They further underscore the importance of targeting negative beliefs about aging, which are modifiable, in prevention efforts designed to forestall accelerated DNA methylation aging.
目的
本研究旨在确定广泛的社会人口学、军事、健康和心理社会因素如何与美国男性退伍军人的大样本、当代、全国代表性样本中加速的 DNA 甲基化衰老（Δ）相关。
方法
对参加国家健康和退伍军人复原力研究（N=1135）的美国欧洲裔男性退伍军人样本进行了数据分析。
结果
终身创伤负担、儿童性创伤和对衰老的负面信念等心理社会因素与Δ独立相关。三个健康变量——糖尿病、高血压和体重指数——也成为Δ的额外相关因素。
结论
该研究结果建立在先前研究的基础上，这些研究表明加速的 DNA 甲基化衰老与创伤性应激之间存在关联，特别强调了儿童性虐待的作用。它们进一步强调了针对可改变的衰老负面信念的重要性，这是预防设计中阻止加速的 DNA 甲基化衰老的重要因素。
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