Arbuthnott J P
Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland.
Microbiol Sci. 1988 Jan;5(1):13-6.
First described in 1978, toxic shock syndrome (TSS) emerged as cause for public concern in 1980 as an acute multisystem disease syndrome associated with Staphylococcus aureus. Epidemiological, clinical and microbiological studies have revealed most of the pieces of the puzzle: a new toxin TSST-1, low antibodies in susceptible individuals, the presence of a focus of S. aureus infection. In menstrual TSS, the role of tampons has generated much controversy. Exactly how the pieces fit together to explain the pathophysiology of TSS at the cellular and molecular levels remains to be elucidated.
中毒性休克综合征（TSS）于1978年首次被描述，1980年作为一种与金黄色葡萄球菌相关的急性多系统疾病综合征引起了公众关注。流行病学、临床和微生物学研究已经揭示了大部分谜团：一种新毒素TSST-1、易感个体中低抗体水平、金黄色葡萄球菌感染灶的存在。在经期中毒性休克综合征中， tampons的作用引发了诸多争议。这些因素究竟如何在细胞和分子水平上共同作用来解释中毒性休克综合征的病理生理学仍有待阐明。
