Rojas L Katerin, Trilla-Fuertes Lucía, Gámez-Pozo Angelo, Chiva Cristina, Sepúlveda Juan, Manso Luis, Prado-Vázquez Guillermo, Zapater-Moros Andrea, López-Vacas Rocío, Ferrer-Gómez María, Mendiola César, Espinosa Enrique, Sabidó Eduard, Ciruelos Eva, Vara Juan Ángel Fresno
Department of Medical Oncology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Katerin L Rojas and Lucía Trilla-Fuertes contributed equally to this work.
Ecancermedicalscience. 2019 Jan 15;13:891. doi: 10.3332/ecancer.2019.891. eCollection 2019.
Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)-which are associated with minor survival rates-lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS).
The main objective of this study was to study differences in tumour protein expression between patients with CNS metastases and those without this kind of spread, and propose new biomarkers.
A retrospective study was performed. Targeted proteomics and statistical analyses were used to identify possible biomarkers.
Proteins were quantified by a targeted proteomics approach and protein expression data were successfully obtained from 51 triple negative formalin-fixed paraffin-embedded samples. ISG15, THBS1 and AP1M1 were identified as possible biomarkers related with CNS metastasis development.
Three possible biomarkers associated with CNS metastases in TNBC tumours were identified: ISG15, THBS1 and AP1M1. They may become markers predicting the appearance of CNS infiltration in triple negative BC.
乳腺癌（BC）是女性中最常见的肿瘤。三阴性肿瘤（TNBC）——与较低生存率相关——缺乏预测对抗癌药物反应的标志物。三阴性肿瘤常转移至中枢神经系统（CNS）。
本研究的主要目的是研究有中枢神经系统转移的患者与无此类转移的患者之间肿瘤蛋白表达的差异，并提出新的生物标志物。
进行了一项回顾性研究。采用靶向蛋白质组学和统计分析来识别可能的生物标志物。
通过靶向蛋白质组学方法对蛋白质进行定量，并成功从51个三阴性福尔马林固定石蜡包埋样本中获得蛋白质表达数据。ISG15、THBS1和AP1M1被鉴定为与中枢神经系统转移发展相关的可能生物标志物。
在三阴性乳腺癌肿瘤中鉴定出三种与中枢神经系统转移相关的可能生物标志物：ISG15、THBS1和AP1M1。它们可能成为预测三阴性乳腺癌中枢神经系统浸润出现的标志物。
