Department of Infectious Diseases, Drug Discovery Division, Southern Research, Birmingham, AL, USA.
Chemistry Department, Drug Discovery Division, Southern Research, Birmingham, AL, USA.
Commun Biol. 2019 Feb 15;2:66. doi: 10.1038/s42003-019-0310-0. eCollection 2019.
Oxygenated unsaturated fatty acids, known as oxylipins, are signaling molecules commonly used for cell-to-cell communication in eukaryotes. However, a role for oxylipins in mediating communication in prokaryotes has not previously been described. Bacteria mainly communicate via quorum sensing, which involves the production and detection of diverse small molecules termed autoinducers. Here we show that oleic acid-derived oxylipins produced by function as autoinducers of a novel quorum sensing system. We found that this system controls the cell density-dependent expression of a gene subset independently of the quorum sensing systems thus far described in this bacterium. We identified a LysR-type transcriptional regulator as the primary receptor of the oxylipin signal. The discovery of this oxylipin-dependent quorum sensing system reveals that prokaryote-derived oxylipins also mediate cell-to-cell communication in bacteria.
氧合不饱和脂肪酸，又称氧化脂类，是真核生物中常用的细胞间信号分子。然而，氧化脂类在原核生物中介导通讯的作用以前尚未被描述过。细菌主要通过群体感应进行通讯，其中涉及多种称为自诱导物的小分子的产生和检测。在这里，我们表明，由 产生的油酸衍生的氧化脂类作为一种新型群体感应系统的自诱导物。我们发现，该系统独立于迄今为止在该细菌中描述的群体感应系统，控制细胞密度依赖性的基因亚群的表达。我们鉴定出一种 LysR 型转录调节因子作为氧化脂类信号的主要受体。这种氧化脂类依赖性群体感应系统的发现表明，原核生物衍生的氧化脂类也在细菌中介导细胞间通讯。
