Whiteley Marvin, Diggle Stephen P, Greenberg E Peter
School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-7735, USA.
Nature. 2017 Nov 15;551(7680):313-320. doi: 10.1038/nature24624.
This Review highlights how we can build upon the relatively new and rapidly developing field of research into bacterial quorum sensing (QS). We now have a depth of knowledge about how bacteria use QS signals to communicate with each other and to coordinate their activities. In recent years there have been extraordinary advances in our understanding of the genetics, genomics, biochemistry, and signal diversity of QS. We are beginning to understand the connections between QS and bacterial sociality. This foundation places us at the beginning of a new era in which researchers will be able to work towards new medicines to treat devastating infectious diseases, and use bacteria to understand the biology of sociality.
本综述重点介绍了我们如何在相对较新且迅速发展的细菌群体感应（QS）研究领域的基础上继续发展。我们现在对细菌如何利用群体感应信号相互交流并协调其活动有了深入的了解。近年来，我们对群体感应的遗传学、基因组学、生物化学和信号多样性的理解取得了非凡的进展。我们开始理解群体感应与细菌社会性之间的联系。这一基础使我们处于一个新时代的开端，在这个时代，研究人员将能够致力于研发治疗毁灭性传染病的新药，并利用细菌来理解社会性生物学。
