Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Clin Exp Dermatol. 2019 Aug;44(6):620-624. doi: 10.1111/ced.13862. Epub 2019 Feb 21.
Despite its high contagiousness, high recurrence rate and potential for malignant transformation, effective treatments for condyloma acuminatum (CA) have not yet been developed. Accordingly, it is necessary to clarify the mechanisms underlying CA development.
To investigate the expression and significance of the proteins Wnt-1 and TSLC1 in patients with CA and in normal foreskin controls.
Wnt-1 and TSLC1 were assessed by immunohistochemistry in 45 patients with CA.
Positive expression rates of Wnt-1 and TSLC1 were 82.22% (37/45) and 37.78% (17/45), respectively, in CA tissues, and 29.17% (7/24) and 91.67% (22/24), respectively, in normal foreskin controls. Wnt-1 expression intensity in CA was markedly higher (positive to strongly positive) than that in normal controls (negative to weakly positive), whereas TSLC1 expression intensity ranged from weakly positive to positive in CA, and nearly strongly positive in the normal control group. The differences in the positive expression rate and expression intensity of Wnt-1 and TSLC1 between the two groups were statistically significant (P < 0.05). In addition, Wnt-1 and TSLC1 were negatively correlated. (r = -0.336, P < 0.05).
Overexpression of Wnt-1 and low expression of TSLC1 may be associated with the growth of CA. These findings may provide a basis for the development of therapies to prevent recurrence or malignant transformation of CA.
尽管尖锐湿疣具有高度传染性、高复发率和潜在恶性转化的可能性，但尚未开发出有效的尖锐湿疣治疗方法。因此，有必要阐明尖锐湿疣发展的机制。
研究 Wnt-1 和 TSLC1 蛋白在尖锐湿疣患者和正常包皮对照中的表达及意义。
采用免疫组织化学法检测 45 例尖锐湿疣患者和 24 例正常包皮组织中 Wnt-1 和 TSLC1 的表达。
尖锐湿疣组织中 Wnt-1 和 TSLC1 的阳性表达率分别为 82.22%（37/45）和 37.78%（17/45），正常包皮组织中分别为 29.17%（7/24）和 91.67%（22/24）。尖锐湿疣组织中 Wnt-1 的表达强度明显高于正常对照组（阳性至强阳性），而 TSLC1 的表达强度在尖锐湿疣组织中从弱阳性到阳性不等，在正常对照组中几乎为强阳性。两组间 Wnt-1 和 TSLC1 的阳性表达率和表达强度差异均有统计学意义（P<0.05）。此外，Wnt-1 和 TSLC1 呈负相关（r=-0.336，P<0.05）。
Wnt-1 的过表达和 TSLC1 的低表达可能与尖锐湿疣的生长有关。这些发现可能为预防尖锐湿疣复发或恶性转化的治疗方法的开发提供依据。
