Su Xiang-Yang, Lai Wei, Zhu Hui-Lan, Su Zu-Lan, Guo Shao-Zhong, Lin Su-Xia
Department of Dermatology and Venerology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510 630, P.R. China.
Ai Zheng. 2004 Nov;23(11):1346-9.
BACKGROUND & OBJECTIVE: About 3%-10% of condyloma acuminatum (CA) may develop into cancer. Some studies indicated that homologous deletion of p16 gene is a major factor that causes cancerization of CA. This study was to detect expression of P16 protein in CA tissues and its cancerization tissues, and to investigate relationship of abnormal expression of P16 and cancerization of CA.
A total of 75 skin biopsy specimens were collected, including 30 normal skin samples (control group), 35 CA samples, and 10 cancerized CA samples. Expression of P16 was tested by LSAB immunohistochemistry, and relationship of P16 and cancerization of CA was statistically analyzed.
CA and normal skin tissues showed weakly positive expression of P16, no significant difference exist (P< 0.05). Cancerized CA tissues showed positive or strongly positive expression of P16, significantly stronger than CA and normal skin tissues (P< 0.05).
Positive and strongly positive expression of P16 in CA tissue implied risk of cancerization of CA. P16 may be a useful predictor for cancerization of CA.
约3%-10%的尖锐湿疣（CA）可发生癌变。一些研究表明，p16基因的同源性缺失是导致CA癌变的主要因素。本研究旨在检测CA组织及其癌变组织中P16蛋白的表达情况，并探讨P16异常表达与CA癌变的关系。
共收集75份皮肤活检标本，其中包括30份正常皮肤样本（对照组）、35份CA样本和10份CA癌变样本。采用LSAB免疫组织化学法检测P16的表达情况，并对P16与CA癌变的关系进行统计学分析。
CA组织和正常皮肤组织中P16呈弱阳性表达，差异无统计学意义（P<0.05）。CA癌变组织中P16呈阳性或强阳性表达，明显强于CA组织和正常皮肤组织（P<0.05）。
CA组织中P16呈阳性及强阳性表达提示CA有癌变风险。P16可能是CA癌变的一个有用预测指标。
